Recombinant Mouse Duffy antigen/chemokine receptor (Darc)

1. Our findings in mice suggest that DARC alters the severity and resolution of AHR. These findings are complimented by our human analyses in which select DARC SNPs are associated with worse asthma control and symptoms. PMID: 28471517
2. DARC was exquisitely restricted to post-capillary and small collecting venules and completely absent from arteries, arterioles, capillaries, veins, and most lymphatics in every tissue analyzed. Intravital microscopy showed that adhesive leukocyte-endothelial interactions were restricted to DARC(+) venules. DARC was detectable over the entire circumference of V-ECs, but was more concentrated at cell-cell junctions. PMID: 28526034
3. DARC regulates recruitment of osteoclast precursors at the inflammation site PMID: 27376530
4. Nucleated erythroid cells had high expression of ACKR1, which facilitated their direct contact with hematopoietic stem cells. The absence of erythroid ACKR1 altered mouse hematopoiesis including stem and progenitor cells, which ultimately gave rise to phenotypically distinct neutrophils that readily left the circulation, causing neutropenia. PMID: 28553950
5. The DARC/CD234 is expressed on macrophages and stabilizes CD82 on long-term repopulating hematopoietic stem cells, promoting their quiescence. PMID: 26996598
6. Ackr1 deficiency appears to be protective in the ApoE knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine expression as well as T-cell subset frequency and inflammatory macrophage content. PMID: 25858253
7. the results suggest that normal motor function and behavior may partly depend on negative regulation of Purkinje cell activity by Ackr1. PMID: 24997773
8. Darc plays a role in modulating the regulation of inflammatory response to bone injury and that lack of Darc expression promotes cartilage formation in fracture calluses but does not affect bony union or fracture healing at 21 days post-fracture. PMID: 24146983
9. The data showed a role for erythrocyte DARC as a chemokine reservoir and that endothelial DARC contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier. PMID: 24625696
10. DARC is crucial for chemokine-mediated leukocyte recruitment in vivo. PMID: 20061440
11. Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion. PMID: 11929753
12. Vascular endothelial cells may induce Duffy protein to regulate leukocytes and/or chemokine trafficking PMID: 12697152
13. role of the Duffy antigen and glycophorin A as receptors for rodent malaria parasite invasion of erythrocytes PMID: 15278442
14. we have defined the binding domain on the mDuffy protein for Plasmodium yoelii binding to erythrocytes PMID: 16386320
15. DARC functions to clear angiogenic CXC chemokines from the prostate tumor microcirculation PMID: 16394268
16. Darc regulates bone mineral density (BMD)negatively by increasing osteoclast formation. Darc is proposed as a candidate gene for chromosome 1 BMD QTL2. PMID: 17416748
17. Results indicate that endothelial cell overexpression of mDARC increased leukocyte trafficking to the tumor, reduced the growth of blood vessels into the tumor, and reduced the growth rate of melanoma. PMID: 17942909
18. Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation PMID: 19064726
19. renal inflammation developed more rapidly in DARC-deficient mice, without affecting the extent of renal injury at later time points PMID: 19498001
20. DARC regulates lung inflammation by controlling the distribution and presentation of chemokines that bind CXCR2. PMID: 19499525

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KEGG: mmu:13349

STRING: 10090.ENSMUSP00000045134

UniGene: Mm.6393