ACKR1

ACKR1 is an atypical chemokine receptor 1, also known as FY, Dfy, GPD, DARC, GpFy, CCBP1, CD234, WBCQ1, DARC/ACKR1, etc. ACKR1 is encoded by the human ACKR1 gene, which is located on chromosome 1 in the 1q23.2 region.
ACKR1 regulates the immune response primarily by binding, internalizing and degrading chemokines. As a “silent” scavenger receptor, ACKR1 does not signal through G proteins, but rather regulates the bioavailability of chemokines in the circulation by capturing them, preventing excessive circulating chemokine concentrations and systemic leukocyte activation, while also provides a blood reserve (buffer) for chemokines and prolongs their half-life.
ACKR1 plays an important role in the regulation of inflammatory responses and leukocyte migration, and deletion or variation in its expression has been associated with resistance to malaria in specific populations, as well as with certain hematologic disorders.

Validated Data

Activity
Measured by its binding ability in a functional ELISA. Immobilized ACKR1 at 1 μg/ml can bind human CCL2, the EC₅₀ of human CCL2 protein is 48.64-60.24 μg/ml.

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DARC Recombinant Monoclonal Antibody (CSB-RA287686A0HU)

Validated Data

Overlay Peak curve showing 293 cells stained with CSB-RA287686A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1µg/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

The following ACKR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ACKR1 Antibodies

ACKR1 Proteins

ACKR1 Antibodies

ACKR1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA006504GA01HU	ACKR1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA008513	ACKR1 Antibody	Human	IF, ELISA
CSB-PA624105LA01HU	ACKR1 Antibody	Human, Mouse	ELISA, WB, IF
CSB-RA287686A0HU	DARC Recombinant Monoclonal Antibody	Human	ELISA, FC

ACKR1 Proteins

ACKR1 Proteins for Bos indicus (Zebu)

Code	Product Name	Source
CSB-CF769670BUL	Recombinant Bos indicus Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP769670BUL1 CSB-EP769670BUL1 CSB-BP769670BUL1 CSB-MP769670BUL1 CSB-EP769670BUL1-B	Recombinant Bos indicus Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF884401BO	Recombinant Bovine Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP884401BO1 CSB-EP884401BO1 CSB-BP884401BO1 CSB-MP884401BO1 CSB-EP884401BO1-B	Recombinant Bovine Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF889540MO	Recombinant Mouse Duffy antigen/chemokine receptor (Darc)	in vitro E.coli expression system
CSB-YP889540MO1 CSB-EP889540MO1 CSB-BP889540MO1 CSB-MP889540MO1 CSB-EP889540MO1-B	Recombinant Mouse Duffy antigen/chemokine receptor (Darc), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-CF853305MOW	Recombinant Macaca mulatta Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP853305MOW1 CSB-EP853305MOW1 CSB-BP853305MOW1 CSB-MP853305MOW1 CSB-EP853305MOW1-B	Recombinant Macaca mulatta Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Papio hamadryas (Hamadryas baboon)

Code	Product Name	Source
CSB-CF822099ERJ	Recombinant Papio hamadryas Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP822099ERJ1 CSB-EP822099ERJ1 CSB-BP822099ERJ1 CSB-MP822099ERJ1 CSB-EP822099ERJ1-B	Recombinant Papio hamadryas Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Saguinus imperator (Emperor tamarin)

Code	Product Name	Source
CSB-CF836101SVX	Recombinant Saguinus imperator Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP836101SVX1 CSB-EP836101SVX1 CSB-BP836101SVX1 CSB-MP836101SVX1 CSB-EP836101SVX1-B	Recombinant Saguinus imperator Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Sapajus apella (Brown-capped capuchin) (Cebus apella)

Code	Product Name	Source
CSB-CF839207DQU	Recombinant Cebus apella Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP839207DQU1 CSB-EP839207DQU1 CSB-BP839207DQU1 CSB-MP839207DQU1 CSB-EP839207DQU1-B	Recombinant Cebus apella Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-CF842558EQV	Recombinant Pan troglodytes Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP842558EQV1 CSB-EP842558EQV1 CSB-BP842558EQV1 CSB-MP842558EQV1 CSB-EP842558EQV1-B	Recombinant Pan troglodytes Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Gorilla gorilla gorilla (Western lowland gorilla)

Code	Product Name	Source
CSB-CF846503GGZ	Recombinant Gorilla gorilla gorilla Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP846503GGZ1 CSB-EP846503GGZ1 CSB-BP846503GGZ1 CSB-MP846503GGZ1 CSB-EP846503GGZ1-B	Recombinant Gorilla gorilla gorilla Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

Code	Product Name	Source
CSB-CF856816SWC	Recombinant Saimiri boliviensis boliviensis Duffy antigen/chemokine receptor (DARC)	in vitro E.coli expression system
CSB-YP856816SWC1 CSB-EP856816SWC1 CSB-BP856816SWC1 CSB-MP856816SWC1 CSB-EP856816SWC1-B	Recombinant Saimiri boliviensis boliviensis Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACKR1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP624105HU1 CSB-EP624105HU1 CSB-BP624105HU1 CSB-MP624105HU1 CSB-EP624105HU1-B	Recombinant Human Duffy antigen/chemokine receptor (DARC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF624105HU	Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active)	in vitro E.coli expression system
CSB-MP624105HU	Recombinant Human Atypical chemokine receptor 1 (ACKR1)-VLPs	Mammalian cell

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ACKR1

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