Recombinant Mouse G protein-activated inward rectifier potassium channel 1 (Kcnj3)

1. Ethanol activates GIRK1 by shifting the conformational equilibrium processes, which are responsible for the gating of GIRK, to stabilize an open conformation of the cytoplasmic ion gate. PMID: 29581303
2. Kir 3.1 channels are important for supraspinal antinociception and presynaptic GABA release inhibition by oxycodone in the femur bone cancer model PMID: 25521524
3. GABA neurons in the ventral tegmental area express GIRK1 (and GIRK2) subunits. PMID: 25948263
4. K(IR)3.1 channels play a primary role in the antinociceptive effects of oxycodone, but not those of morphine, at supraspinal sites and suggest that supraspinal K(IR)3.1 channels are responsible for the unique analgesic profile of oxycodone. PMID: 24117458
5. siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1. PMID: 23829864
6. Discontinuous and sometime opposing elements in Girk1 underlie the Girk1-dependent potentiation of receptor-dependent and receptor-independent heteromeric channel activity. PMID: 23236146
7. Mechanism for functional dysregulation in the dorsal raphe follows tyrosine phosphorylation of repeated stress-activated Kir3.1 channels. PMID: 22956823
8. NMR analyses of the Gbetagamma binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1). PMID: 21075842
9. Agonist-induced localization of Gq-coupled receptors and G protein-gated inwardly rectifying K+ (GIRK) channels to caveolae determines receptor specificity of phosphatidylinositol 4,5-bisphosphate signaling PMID: 21041306
10. The atrial potassium channel, I(KACH), ion channel gating is accelerated in atrial myocytes through the RGS6/Gbeta5 complex. PMID: 20884879
11. Dopamine neurons from Girk1 knock-out mice (and Girk2) exhibited elevated glutamatergic neurotransmission and increased synaptic levels of AMPA glutamate receptors. PMID: 20557431
12. Data suggest HL-1 cells express GIRK1/4 and M2 muscarinic receptors and are a good model to study acetylcholine-activated potassium currents. PMID: 20186548
13. confers properties to I(KACh) that enhance channel activity and that Kir3.4 homomultimers do not contribute significantly to the muscarinic-gated potassium current PMID: 12374786
14. Kcnj3 is associated with idiopathic generalised epilepsy syndromes by genotype. PMID: 12458027
15. A cytoplasmic pore in the GIRK1 channel extends the ion pathway to 60 A, nearly twice the length of a canonical transmembrane K(+) channel. The cytoplasmic pore is lined by acidic and hydrophobic amino acids; polyamines block this pore. PMID: 12507423
16. We found GIRK1 and GIRK2 subunits in the spinal cord dorsal horn; GIRK1 and GIRK2 knock-out mice exhibited hyperalgesia. Furthermore GIRK1 and GIRK2 knock-out mice showed decreased analgesic responses after spinal administration of higher morphine doses PMID: 15028774
17. Data show that the composition of the Kir3.1 and Kir 3.4 subunits of the G protein-gated potassium channel changes during embryonic development. PMID: 15467839
18. phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress PMID: 16223722
19. GIRK1 exhibited the most widespread and robust labeling in the cerebellum, with labeling particularly prominent in granule cells,Purkinje neurons,basket cells. PMID: 18088366
20. GIRK channels make important contribution to a range of behaviors and may represent points of therapeutic intervention in disorders of anxiety, spasticity and reward PMID: 18194467
21. This study investigates the action of CRF on G-protein-linked inhibitory postsynaptic currents (IPSCs) mediated by GIRK (Kir3) channels in dopamine neurons. PMID: 19279570
22. The association of GIRK channels and GABA(B) receptors with excitatory synapses at both post- and pre-synaptic sites indicates their intimate involvement in the modulation of glutamatergic neurotransmission in the cerebellum. PMID: 19558451
23. two spermine molecules bind to a tetramer of Kir3.1/GIRK1 with a dissociation constant of 26 microM, which is lower than other blockers. PMID: 19620244
24. The authors present a crystal structure of the cytoplasmic portion of a Kir channel with five ions bound and demonstrate that a constriction near the intracellular end of the pore, acting as a gasket, prevents K(+) ions from bypassing the blocker. PMID: 19915587

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KEGG: mmu:16519

STRING: 10090.ENSMUSP00000063329

UniGene: Mm.418451