Recombinant Mouse G-protein coupled receptor 56 (Gpr56)

1. all hematopoietic stem cells (HSCs) in mouse bone marrow mononuclear cells express GPR56 protein on their surface and that GPR56 is a positive marker for HSCs. PMID: 29225194
2. Collagen III protected beta-cells from cytokine-induced apoptosis, triggered increases in [Ca(2+)]i and potentiated glucose-induced insulin secretion from WT islets but not from Gpr56(-/-) islets. Deletion of GPR56 did not affect glucose-induced insulin secretion in vitro and it did not impair glucose tolerance in adult mice PMID: 29855662
3. Deletion of G-protein coupled receptor 56 (GPR56) in the mouse germline abrogated progastrin-dependent colonic mucosal proliferation and increased apoptosis. PMID: 28380450
4. determine the crystal structure of the GPR56 extracellular domain. PMID: 27657451
5. knockdown of Gpr56 delayed onset of HOXA9/MEIS1-induced AML PMID: 27063597
6. GPR56 is a cell-autonomous regulator of oligodendrocyte development PMID: 25607655
7. Although GPR56 is abundantly and selectively expressed by primitive HSPCs, its high level expression is largely dispensable for steady-state and regenerative hematopoiesis. PMID: 25840412
8. we knocked down GPR56 in cardiomyocytes and found that GPR56 promoted Ang II-induced cardiomyocyte hypertrophy and it contributed to PCBP2 effects on cardiomyocyte hypertrophy PMID: 26116532
9. Data show that Gpr56, a G-coupled protein receptor, is required for hematopoietic cluster formation during transdifferentiation process in endothelial to hematopoietic cell transition (EHT). PMID: 25547674
10. These data illustrate a signaling pathway through GPR56 which regulates muscle hypertrophy associated with resistance/loading-type exercise. PMID: 25336758
11. adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation PMID: 24949629
12. Role for TG2 in GPR56-mediated melanoma inhibition. The uncovered antagonistic relationship between GPR56 and TG2 proposes a mechanism by which extracellular matrix accumulation/crosslinking in tumors may be reversed. PMID: 24356421
13. GPR56 functions together with alpha3beta1 integrin in regulating cerebral cortical development. PMID: 23874761
14. We revealed that GPR56 is expressed in multiple cell types in the preplate, marginal zone, subventricular zone, and ventricular zone in the developing cerebral cortex PMID: 22351047
15. GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms PMID: 21349848
16. Data suggest that GPR56 might act to establish a spatial and/or temporal cue for asymmetric cord remodeling during male gonad development. PMID: 20981830
17. preferential expression in neuronal progenitor cells of the cerebral cortical ventricular and subventricular zones duing periods of neurogenesis PMID: 15044805
18. potential pleiotrophic role of secretin during embryonic development PMID: 16888225
19. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior PMID: 17008357
20. Mutation of the SCTR gene could lead to mild polydipsia and polyuria PMID: 17283064
21. mutations in GPR56 impair trafficking of the mutant protein to the plasma membrane, thus providing insights into how BFPP-associated mutations affect GPR56 function PMID: 17576745
22. These results define the biochemical properties of GPR56 protein, and suggest that the expression of GPR56 protein is suppressed in human pancreatic cancer cells. PMID: 17932623
23. results indicate that GPR56 participates in the regulation of neural progenitor cells movement through the Galpha(12/13) and Rho signaling pathway, suggesting its important role in the development of the central nervous system PMID: 18378689
24. GPR56 regulates pial basement membrane integrity and cortical lamination. PMID: 18509043
25. These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. PMID: 19515912

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KEGG: mmu:14766

STRING: 10090.ENSMUSP00000090959

UniGene: Mm.290834