Recombinant Mouse Intercellular adhesion molecule 2(Icam2)

Code CSB-CF010950MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Icam2
Uniprot No. P35330
Alternative Names Icam2; Icam-2; Intercellular adhesion molecule 2; ICAM-2; Lymphocyte function-associated AG-1 counter-receptor; CD antigen CD102
Species Mus musculus (Mouse)
Expression Region 23-277
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Gene References into Functions
  1. Data show that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate T follicular helper (Tfh)-B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion. PMID: 28939548
  2. Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells. PMID: 24704826
  3. ICAM-2 regulates endothelial barrier function and permeability through a pathway involving N-Cadherin, ERMs and Rac-1 PMID: 24593809
  4. These findings highlight novel roles for ICAM-2 in mediating luminal neutrophil crawling and the effect on subsequent levels of extravasation. PMID: 24317296
  5. show that the sequential expression of CD40 and Icam2 delineate a transition in the acquisition of the blood potential from hemangioblast to hemogenic endothelium leading to the formation of primitive and definitive hematopoietic progenitors. PMID: 20506544
  6. Data report the crystal structure of the radixin FERM (4.1 and ERM) domain complexed with the intercellular adhesion molecule-2 (ICAM-2) cytoplasmic peptide. PMID: 12554651
  7. ICAM-2 and ICAM-1 have redundant functions in lymphocyte recirculation through lymph nodes, but ICAM-2 is not required for the migration of T effector cells into inflamed skin. PMID: 12928410
  8. The 60 kDa protein, the murine homologue of ICAM-2 (CD102), recognized by the BF/32 antibody was widely expressed on lymphocytes PMID: 18680764

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily, ICAM family
Tissue Specificity Expressed in endothelial cells and leukocytes. High levels found in lung.
Database Links

KEGG: mmu:15896

STRING: 10090.ENSMUSP00000001055

UniGene: Mm.394


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