Recombinant Mouse Leukotriene B4 receptor 2 (Ltb4r2)

1. FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages PMID: 28546450
2. This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL PMID: 28053185
3. the data show that the two leukotriene B4 receptors have opposing roles in the sensitization of peripheral sensory neurons forming a self-restricting system. PMID: 28242764
4. These results show that 12-HHT/BLT2 enhances epithelial barrier function by increasing CLDN4 expression via the Galphai protein-p38 MAPK pathway. PMID: 26527063
5. Data indicate that leukotriene B4 receptor 2 protein BLT2-deficient mice exhibited impaired re-epithelialization and delayed wound closure after skin punching. PMID: 24821912
6. Findings indicate that BLT2 has a protective role in allergic airway inflammation and that diminished BLT2 expression in CD4(+) T cells may contribute to the pathophysiology of asthma. PMID: 23603839
7. Selective inhibition of the BLT2 receptor in mice reduces the release of vascular reactive oxygen species and improves endothelial function in mice PMID: 21755457
8. Results suggest a direct anti-inflammatory role of BLT2 that is distinct from the proinflammatory roles of BLT1. PMID: 20667973
9. our results suggest that the BLT2-Nox1-reactive oxygen species cascade is a previously unsuspected mediatory signaling mechanism to Th2 cytokine production in Ag-stimulated BMMCs PMID: 20952677
10. BLT2-deficient mice develop normally; analysis of immune cells shows that disruption of BLT2 does not alter BLT1 expression or function. PMID: 20656922
11. BLT2 plays a pivotal, mediatory role in the pathogenesis of asthma, acting through a "reactive oxygen species-NF-kappaB"-linked inflammatory signaling pathway. PMID: 19448154
12. 360 amino acid sequence determined and aligned with human sequence PMID: 12895595
13. BLT2 is a leukotriene B4 receptor with a role in ERK activation and cell migration of primary mouse keratinocytes PMID: 15866883
14. demonstrates expression of functional Leukotriene B4 receptors, both BLT1 and BLT2, in murine and human mast cells and a regulatory role for stem cell factor in their expression PMID: 16920986
15. 12-HHT is a natural lipid agonist of BLT2 in vivo and induces chemotaxis of mast cells PMID: 18378794
16. The BLT2 receptor is involved in 12(S)-lipoxygenase-product-induced scratching in ICR mice. PMID: 18536755

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KEGG: mmu:57260

STRING: 10090.ENSMUSP00000048358

UniGene: Mm.159670