Recombinant Mouse Nociceptin receptor (Oprl1)

1. nociceptin opioid receptor agonists are promising drugs for treating pain in sickle cell anemia. PMID: 26294734
2. These knock-in mice have NOP receptors that function both in vitro and in vivo and have provided a detailed characterization of NOP receptors in brain, spinal cord, and DRG neurons. PMID: 26290245
3. Oprl1 is associated with amygdala function, fear processing, and posttraumatic stress disorder symptoms. PMID: 23740899
4. Data suggest that NOPR and MOPR (mu-type opioid receptor) in spinal cord independently drive antinociception; NOPR/MOPR ligands attenuate neuropathic/inflammatory pain and have high antinociceptive potency with low tolerance development. PMID: 23652222
5. Data suggest that nociceptin receptor/nociceptin signaling plays a role in the disease pathogenesis of inflammatory bowel diseases. PMID: 22449384
6. The results of this study demonstrated the contribution of the NOP receptor in controlling food intake and meal pattern, as well as glutamate release and GIRK1 channel activity at POMC synapses. PMID: 20510254
7. These results suggest differential requirements for ORL(1) in the mediation of neuroimmune effects exerted at different times after an immune challenge. PMID: 19913923
8. OPR is not crucial for development of either acute or neuropathic nociceptive responses, or for the regulation of full receptor-mediated responses to opioid agonists PMID: 12217419
9. The region-specific up-regulation of the opioid receptor-like 1 receptor indicates a tonic role for nociceptin/orphanin FQ in some brain structures and may suggest the peptide regulates the receptor expression in these regions. PMID: 12605902
10. Place cells in nociceptin receptor knockout mice were abnormal in several ways: they were less stable, had noisier positional firing patterns, larger firing fields and higher discharge rates inside and outside the firing fields PMID: 15774528
11. NOC receptor is involved in hippocampal cholinergic function PMID: 15979594
12. RGS19 prefers regulating ORL1 receptor signaling over other opioid receptors, and the N-terminal domain of RGS19 plays a crucial role in its receptor preference PMID: 16219326
13. nociceptin receptor has a role in the antinociceptive action of nitrous oxide PMID: 16931689
14. Nociceptin released from interneurons by their high-frequency activation is a novel endogenous neuromodulator that negatively regulates induction of long-term potentiation in the hippocampus through direct modulation of pyramidal cells. PMID: 17475793
15. the ability of buprenorphine to interact with the ORL1 receptor modulates its acute motor stimulatory and rewarding effects. PMID: 18634857
16. findings demonstrate the existence of functional antagonism between nociceptin opioid peptide receptor and NMDA receptors that predominantly contributes to modulation of conditioned fear learning which involves spatial-processing demands PMID: 19100850
17. Mice lacking the influence of endogenous N/OFQ are hypersensitive to nicotine in most measures, showing a role of endogenous nociceptin in modulating or mediating the acute effects of nicotine, and possibly nicotine addiction. PMID: 19371589

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KEGG: mmu:18389

STRING: 10090.ENSMUSP00000071513

UniGene: Mm.285075