Recombinant Mouse P2Y purinoceptor 13 (P2yr13)-VLPs

1. Conclude that, at motor nerve terminals, the Gi/o protein-coupled P2Y receptors implicated in presynaptic inhibition of spontaneous and evoked acetylcholine release are of the subtype P2Y13. This study provides new insights into the types of purinergic receptors that contribute to the fine-tuning of cholinergic transmission at mammalian neuromuscular junction. PMID: 27058149
2. The P2Y13 receptor protects against atherosclerosis, primarily through its role in hepatobiliary reverse cholesterol transport PMID: 25770145
3. P2Y13 receptor activation is crucial in mediating the high-fat-diet and palmitic acid-induced myenteric neuronal loss. PMID: 24510452
4. Up-regulation of HDL-cholesterol metabolism via activation of the P2Y13R using agonists could promote reverse cholesterol transport and promote inhibition of atherosclerosis progression in mice. PMID: 24769858
5. Findings indicate that the P2Y13 R plays an important role in the balance of osteoblast and adipocyte terminal differentiation of bone marrow progenitors. PMID: 23629754
6. P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development PMID: 24487286
7. The regulation of P2Y13-R expression and provided evidence that P2Y13-R is tightly regulated by constitutive ubiquitination in the ER, and subsequent proteasome degradation. PMID: 24030815
8. The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading. PMID: 23362109
9. results demonstrate a crosstalk between two metabotropic and one ionotropic purinergic receptor that regulates cAMP levels through adenylate cyclase 5 and modulates axonal elongation triggered by neurotropic factors and the PI3K-Akt-GSK3 pathway PMID: 22250198
10. P2Y13 receptor in invloves in suppression of neuronal differentiation. P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases. PMID: 22521313
11. study to examine the role of P2Y13 receptor in bone homeostasis both in vivo and in vitro; deletion of the P2Y13 receptor leads to less trabecular bone in mice, by affecting both osteoblasts and osteoclasts PMID: 22108801
12. experiments assess a role for the purinergic receptor P2Y(13) in the regulation of lipoprotein metabolism and demonstrate that modulating its activity could be of benefit to the treatment of dyslipidemia in people PMID: 20817122
13. results show a previously unrecognized role of the purinergic P2Y13 receptor in the induction of the Nrf2/HO-1 antioxidant response and in protection against oxidative stress PMID: 20447456
14. study shows P2Y(13)-deficient mice exhibited a decrease in hepatic HDL cholesterol uptake, hepatic cholesterol content, and biliary cholesterol output, data indicate P2Y13 activity is involved in macrophage-to-feces reverse cholesterol transport PMID: 20830789
15. The brackage of P2ry13 protein receptor results in enhanced ERK1/2, Akt/PKB and CREB phosphorylation mechanisms involved in beta-cell survival. PMID: 19915796
16. (p2y13 purinoceptor) PMID: 11961076

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KEGG: mmu:74191

STRING: 10090.ENSMUSP00000044730

UniGene: Mm.90067