Recombinant Mouse Platelet glycoprotein Ib alpha chain (Gp1ba)

1. leukocyte Mac-1 and platelet GPIbalpha are involved in thrombosis PMID: 28555620
2. GPIbbeta has a repressor function in thrombus formation PMID: 27148783
3. this study shows that atheroma formation is inhibited in GPIba-deficient mice on atherosclerosis-prone background PMID: 27206768
4. Thrombin cleavage of platelet PAR4 promotes leukocyte recruitment to sites of vascular injury. This process is negatively regulated by GPIbalpha. PMID: 26204458
5. GPIbalpha-mediated interactions between platelets and endothelial cells, as well as leukocytes, support innate immune cell recruitment and promote arteriogenesis-establishing platelets as critical players in this process. PMID: 25550202
6. Atherosclerosis reduction in mice lacking GPIbalpha may not result from the defective GPIbalpha-ligand binding, but more likely is a consequence of functional defects of GPIbalpha-/- platelets and reduced blood platelet counts. PMID: 25104056
7. Data suggest that targeting platelet receptor glycoprotein Ibalpha (GPIbalpha)-von Willebrand factor VWF-A1 binding interface may offer a therapeutic approach to reducing platelet-driven thrombosis. PMID: 25293780
8. Following endothelial damage, platelet cross-linking during closure of the vessel lumen is mediated by GPIbalpha-VWF interactions. PMID: 24553181
9. These data indicate an important role for the platelet adhesion receptor GPIb-IX in endotoxin-induced thrombosis and thrombocytopenia. PMID: 24051142
10. Platelet IKKbeta deficiency increases the formation of injury-induced arterial neointimal tissue via delayed glycoprotein Ibalpha shedding. PMID: 23241410
11. these data demonstrate that coordinated expression of GPIbalpha and filamin is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets. PMID: 22174152
12. Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV for MP-dependent cleavage. PMID: 22101895
13. miscarriage occurred in the majority of pregnancies in a model of anti-GPIbalpha-mediated fetal and neonatal immune thrombocytopenia (FNIT), which was far more frequent than in anti-integrinbeta3-mediated FNIT PMID: 22019589
14. Data show that the surface-bound VWF appears as a large, linear structure on the surface of 50% of the PT-VWD platelets. PMID: 19808696
15. Molecular models of the seven leucine-rich repeats of human and mouse GPIb alpha show 68% sequence homology, with no insertions or deletions in the repeat. PMID: 11858495
16. Expression of the IL-4Ralpha/Gp1ba fusion sequence in a murine Bernard-Soulier syndrome model led to a 2-fold increase in platelet count and a 50% reduction in platelet size, confirming a critical role for the Gp1ba extracytoplasmic domain in hemostasis. PMID: 12200373
17. the GP Ibalpha cytoplasmic tail sequestered signaling proteins during megakaryocytopoiesis PMID: 15271795
18. GPIbalpha and GPV are shed through an ADAM17-dependent mechanism after aspirin administration PMID: 16179345
19. Absence of GP Ibalpha function has a more profound antithrombotic effect in vivo than absence of the GP VI-dependent pathway of collagen-induced adhesion/activation PMID: 16961609
20. ADAP as a component of inside-out signaling pathways that couple GP Ib-IX-V and other platelet agonist receptors to alphaIIbbeta3 activation. PMID: 17003372
21. GPIbalpha absolutely is required for recruitment of platelets to both exposed subendothelium and thrombi under arterial flow conditions. PMID: 17075060
22. support the hypothesis that platelet GP Ib-IX functions that support normal hemostasis or pathologic thrombosis also contribute to tumor malignancy PMID: 17494758
23. VWF(-/-) mice expressing the GPIb binding mutant failed to restore thrombus formation and were bleeding for as long as they were observed, confirming the critical importance of the VWF-GPIb interaction PMID: 18487513
24. the domains of GpIbalpha mediating c-Myc-like functions are modular, genetically distinct, and independent of those involved in vWFR signaling. PMID: 19017648

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KEGG: mmu:14723

STRING: 10090.ENSMUSP00000057563

UniGene: Mm.377085