Recombinant Mouse Platelet glycoprotein Ib alpha chain (Gp1ba)

Code CSB-CF009685MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
Uniprot No.
Alternative Names
Gp1ba; Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; CD antigen CD42b
Mus musculus (Mouse)
Expression Region
Target Protein Sequence
Protein Length
Full Length of Mature Protein
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
Gene References into Functions
  1. leukocyte Mac-1 and platelet GPIbalpha are involved in thrombosis PMID: 28555620
  2. GPIbbeta has a repressor function in thrombus formation PMID: 27148783
  3. this study shows that atheroma formation is inhibited in GPIba-deficient mice on atherosclerosis-prone background PMID: 27206768
  4. Thrombin cleavage of platelet PAR4 promotes leukocyte recruitment to sites of vascular injury. This process is negatively regulated by GPIbalpha. PMID: 26204458
  5. GPIbalpha-mediated interactions between platelets and endothelial cells, as well as leukocytes, support innate immune cell recruitment and promote arteriogenesis-establishing platelets as critical players in this process. PMID: 25550202
  6. Atherosclerosis reduction in mice lacking GPIbalpha may not result from the defective GPIbalpha-ligand binding, but more likely is a consequence of functional defects of GPIbalpha-/- platelets and reduced blood platelet counts. PMID: 25104056
  7. Data suggest that targeting platelet receptor glycoprotein Ibalpha (GPIbalpha)-von Willebrand factor VWF-A1 binding interface may offer a therapeutic approach to reducing platelet-driven thrombosis. PMID: 25293780
  8. Following endothelial damage, platelet cross-linking during closure of the vessel lumen is mediated by GPIbalpha-VWF interactions. PMID: 24553181
  9. These data indicate an important role for the platelet adhesion receptor GPIb-IX in endotoxin-induced thrombosis and thrombocytopenia. PMID: 24051142
  10. Platelet IKKbeta deficiency increases the formation of injury-induced arterial neointimal tissue via delayed glycoprotein Ibalpha shedding. PMID: 23241410
  11. these data demonstrate that coordinated expression of GPIbalpha and filamin is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets. PMID: 22174152
  12. Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV for MP-dependent cleavage. PMID: 22101895
  13. miscarriage occurred in the majority of pregnancies in a model of anti-GPIbalpha-mediated fetal and neonatal immune thrombocytopenia (FNIT), which was far more frequent than in anti-integrinbeta3-mediated FNIT PMID: 22019589
  14. Data show that the surface-bound VWF appears as a large, linear structure on the surface of 50% of the PT-VWD platelets. PMID: 19808696
  15. Molecular models of the seven leucine-rich repeats of human and mouse GPIb alpha show 68% sequence homology, with no insertions or deletions in the repeat. PMID: 11858495
  16. Expression of the IL-4Ralpha/Gp1ba fusion sequence in a murine Bernard-Soulier syndrome model led to a 2-fold increase in platelet count and a 50% reduction in platelet size, confirming a critical role for the Gp1ba extracytoplasmic domain in hemostasis. PMID: 12200373
  17. the GP Ibalpha cytoplasmic tail sequestered signaling proteins during megakaryocytopoiesis PMID: 15271795
  18. GPIbalpha and GPV are shed through an ADAM17-dependent mechanism after aspirin administration PMID: 16179345
  19. Absence of GP Ibalpha function has a more profound antithrombotic effect in vivo than absence of the GP VI-dependent pathway of collagen-induced adhesion/activation PMID: 16961609
  20. ADAP as a component of inside-out signaling pathways that couple GP Ib-IX-V and other platelet agonist receptors to alphaIIbbeta3 activation. PMID: 17003372
  21. GPIbalpha absolutely is required for recruitment of platelets to both exposed subendothelium and thrombi under arterial flow conditions. PMID: 17075060
  22. support the hypothesis that platelet GP Ib-IX functions that support normal hemostasis or pathologic thrombosis also contribute to tumor malignancy PMID: 17494758
  23. VWF(-/-) mice expressing the GPIb binding mutant failed to restore thrombus formation and were bleeding for as long as they were observed, confirming the critical importance of the VWF-GPIb interaction PMID: 18487513
  24. the domains of GpIbalpha mediating c-Myc-like functions are modular, genetically distinct, and independent of those involved in vWFR signaling. PMID: 19017648

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Database Links
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