Recombinant Mouse Proteinase-activated receptor 4 (F2rl3)

1. Par-4 activation and binding to TERT are key steps required for inducing the apoptosis of islet beta cells under high-glucose/fatty acid conditions in type 2 diabetes. PMID: 30186877
2. these findings are the first to show that internalization of activated PAR4 is linked to proper ERK1/2 and Akt activation. PMID: 27402844
3. Par4 deficiency offers cardioprotection after acute ischemia reperfusion injury. PMID: 26643815
4. Bladder PAR4 stimulation affected urothelial HMGB1 release. PMID: 27010488
5. Thrombin cleavage of platelet PAR4 promotes leukocyte recruitment to sites of vascular injury. PMID: 26204458
6. PAR4 blockade impairs neutrophil migration in vivo, suggesting that PAR4 plays an important role in the regulation of inflammation PMID: 25118784
7. PAR-4 appears to play a hitherto unsuspected role in diabetic vasculopathy. PMID: 25239438
8. mPAR4 contributes to antibacterial defence during murine pneumococcal pneumonia PMID: 23783078
9. PAR-4 as a potential target for future therapeutic strategies against platelet-mediated liver injury on transplantation. PMID: 24434483
10. Results demonstrate that PAR-4 does not play a significant role during pulmonary fibrosis. PMID: 23024330
11. These data suggest a key role for PAR4 in mediating neutrophil recruitment in a mouse model of pleurisy induced by the activity of trypsin or trypsin-like enzymes PMID: 22517275
12. Data suggest that PAR-4 activation is endogenously involved as a feedback loop to attenuate inflammatory colonic hyperalgesia to colorectal distension. PMID: 22044612
13. PARs are involved in the modulation of joint pain, with PAR-4 being pronociceptive in this tissue. Thus, blockade of articular PAR-4 may be a useful means of controlling joint inflammation and pain [PAR-4]. PMID: 19248120
14. arrestin-2 regulates PAR4-dependent signaling pathways, but not responses to ADP alone, and contributes to thrombus formation in vivo. PMID: 21106537
15. this work demonstrates a key role for PAR-4 in mediating eosinophil recruitment in an allergic pleurisy model in mice PMID: 20829647
16. Data indicate that deficiency of PAR4 protects mice from cerebral ischemia/reperfusion (I/R) injury, partially through inhibition of platelet activation and attenuation of microvascular inflammation. PMID: 20087365
17. The current study proves for the first time that PAR4 is localised in mossy fibre axons. The altered expression in CA3 neurons after ischaemia indicates that PAR4 may be involved in post-ischaemic adaptive mechanisms. PMID: 19859967
18. PAR4 activation mediates the potentially detrimental effects of thrombin on microglia, implying that perspectives of exploiting PAR1 as a potential anti-inflammatory target should be shifted toward PAR4 PMID: 12775717
19. mice that lacked both PAR4 and fibrinogen exsanguinated at birth like prothrombin-deficient mice PMID: 14504091
20. platelets treated with a PAR-4 antagonist, as well as platelets isolated from PAR-4 homozygous null mice, failed to aggregate in response to plasmin; plasmin induces platelet aggregation primarily through slow cleavage of PAR-4. PMID: 14973136
21. PAR4 heterozygosity conferred some protection against metastasis in a melanoma metastasis model PMID: 15031212
22. PAR4 has a role in thrombin signaling in platelets PMID: 15304051
23. Par4 has an important role in tumour suppression, with a particular relevance in the endometrium and prostate. PMID: 15877079
24. Thrombin activation of PAR4 may occur with exosite I available to bind cofactor molecules, like the cleaved form of PAR3. PMID: 17606903
25. An important role for PAR-4 in the Shwartzman reaction; inhibition of PAR-4 signaling in neutrophils could be protective in systemic inflammation and disseminated intravascular coagulation. PMID: 17641206
26. The activation of PAR-4 on platelets is crucial in soluble tissue factor-induced inflammation PMID: 18412955
27. Par4 deficiency of the mother, or the absence of maternal platelets, restores normal development in one-third of Thbd-null embryos PMID: 18490515
28. PAR4 signaling enhances platelet aggregate stability by mechanisms independent of other thrombin-dependent pathways such as fibrin formation. PMID: 18983510
29. results identify PAR(4) as a previously unknown modulator of visceral nociception PMID: 19413681
30. murine platelets are more sensitive to plasmin than human platelets due to differences in the primary sequence of PAR4. In contrast to thrombin-dependent activation of platelets,, mPAR3 inhibits plasmin-induced PAR4 activation. PMID: 19437337
31. findings demonstrated that activation of PAR(4) on colonic dorsal root ganglia neurons suppresses their excitability PMID: 19566587
32. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. PMID: 19586901

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KEGG: mmu:14065

STRING: 10090.ENSMUSP00000054426

UniGene: Mm.12948