Recombinant Mouse Uracil nucleotide/cysteinyl leukotriene receptor (Gpr17)

1. Study defined the differentiation capabilities of GPR17+ cells in rodents after myelin disruption in two different models, the former characterized by diffused immune response against myelin components and strong inflammation (the EAE model), and the latter one consisting in local demyelination induced by a toxic agent (the cuprizone model). PMID: 29424466
2. Transcription factor FoxO1 regulates glucose metabolism and feeding through the expression of Gpr17 in hypothalamic AgRP neurons. PMID: 22682251
3. Conditional knockout of Gpr17 in hypothalamic AgRP neurons improves glucose metabolism and energy homeostasis by increasing central sensitivity to insulin and leptin. PMID: 26180086
4. G protein-coupled receptor, Gpr17, was identified as the target of transcription factor FoxO1 to mediate its function in feeding regulation in hypothalamic AgRP neurons, suggesting it is a new drug target for metabolic disorders via actions on appetite control. PMID: 22682251
5. The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke. PMID: 28594400
6. The loss of Gpr17 in mice led to precocious myelination and an earlier onset of remyelination after demyelination PMID: 27733608
7. uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds. PMID: 28254957
8. GPR17(+) cells--in contrast to GPR17(-) NG2-glia--did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia PMID: 26464068
9. stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway. PMID: 26620557
10. Agrp-Gpr17(-/-) mice show reduced food intake, increased relative energy expenditure, and increased satiety, resulting in leanness and reduced body fat. They also show increased central nervous system sensitivity to insulin and leptin. PMID: 26180086
11. The mouse GPR17 receptor plays a central role in the early response of cardiac stromal cells to ischaemia. PMID: 24909956
12. Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor GPR17. PMID: 24150254
13. GPR17 is a marker for progenitor progression within the oligodendroglial lineage that participates in postacute reactivity of NG2-proteoglycan expressing cells in different injury paradigms. PMID: 21956849
14. analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells PMID: 23288840
15. Study finds that transcription factor FoxO1 exerts integrative control of leptin, insulin, and amino acid signaling in AgRP neurons, effectively coordinating food intake with peripheral metabolism; and identifies of a heretofore unrecognized FoxO1 pathway that regulates food intake through the G protein-coupled receptor, Gpr17. PMID: 22682251
16. GPR17 is expressed by a subpopulation of oligodendrocyte precursor cells, but not by astrocytes; this expression pattern is also confirmed in vivo. In vitro, GPR17 expression is markedly influenced by culturing conditions. PMID: 21264945
17. GPR17 negatively regulates type 1 cysteinyl leukotriene receptor (CysLT1R)-mediated inflammatory cell accumulation in the bronchoalveolar lavage fluid and lung, in both the antigen presentation and downstream phases of allergic pulmonary inflammation. PMID: 20574000
18. GPR17 orchestrates the transition between immature and myelinating oligodendrocytes via an ID protein-mediated negative regulation and may serve as a potential therapeutic target for CNS myelin repair. PMID: 19838178
19. GPR17 may act as a "sensor" that is activated upon brain injury on several embryonically distinct cell types, and may play a key role in both inducing neuronal death inside the ischemic core and in orchestrating the local remodeling/repair response. PMID: 18974869
20. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. PMID: 19561298

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KEGG: mmu:574402

STRING: 10090.ENSMUSP00000063670

UniGene: Mm.391108