Recombinant Mouse fMet-Leu-Phe receptor (Fpr1)

1. FPR1-deficient mice showed a slight but significant decrease of demyelination in the corpus callosum and reduced glial cell activation. PMID: 28466255
2. the FPR1 downstream signaling pathways were competitively inhibited by HCH6-1. Furthermore, HCH6-1 prevented pulmonary neutrophil infiltration and edema along with alveolar damage in LPS-induced ALI in mice. Our findings suggest that HCH6-1, a FPR1 antagonist, may have potential as a new therapeutic agent for treating FPR1-involved inflammatory lung diseases PMID: 28232203
3. Intravital TPLSM revealed that formyl-peptide-FPR1 signaling is responsible for regulating neutrophil chemotaxis to allow migration into the necrotic area in hepatic ischemia-reperfusion injury PMID: 28062700
4. Formylated MHC class Ib binding peptides activate both human and mouse neutrophils primarily through FPR1. PMID: 27907124
5. Blocking of FPR1 completely abrogated the fMet-Leu-Phe-, gliadin- and synthetic peptide-induced migration. PMID: 26378785
6. these results highlight the importance of FPR1 in chemotherapy-induced anticancer immune responses. PMID: 26516201
7. Ovalbumininduced airway inflammation is mediated by upregulation of the TLR2/MyD88/NFkappaB signaling pathway and inhibition of LXA4R. PMID: 25760938
8. Deficiency of formyl peptide receptor 1 is associated with increased inflammation and enhanced liver injury after LPS-stimulation PMID: 24956481
9. these findings identify a novel role of FPR1 as pattern recognition receptors for perceiving the enteric microbiota that promotes repair of mucosal wounds via generation of reactive oxygen species from the enterocyte NOX1. PMID: 24192910
10. Further, these results reveal Fpr1 as a major mediator of host commensal interaction during dysbiosis. PMID: 24034617
11. The mechanism involved impaired early neutrophil recruitment to the liver with Fpr1 being sole receptor for neutrophils to sense Listeria chemoattractant signals and for production of bactericidal superoxide. PMID: 23139859
12. findings may have clinical significance because current smokers and subjects with emphysema showed increased FPR expression in bronchoalveolar fluids and on peripheral neutrophils PMID: 22461430
13. Neutrophil migration into the inflamed mouse colon does not depend on FPR1, but FPR1 contributes in other pathological mechanisms that are harmful during acute inflammation but are protective during chronic inflammation. PMID: 22383080
14. Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3 PMID: 21921027
15. Fpr1 has a role in modulation of anxiety-like behavior and fear memory by regulating glucocorticoid production PMID: 21484271
16. The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils. PMID: 12470609
17. Leukocyte antiadhesive and anti-inflammatory actions of annexin 1 involve this receptor. PMID: 12560218
18. a novel TLR4-linked signaling pathway that selectively couples to the stabilization of FPR1 mRNA. PMID: 17277163
19. The mechanisms through which these two small GTPases Rac1 and Rac2 mediate free barbed ends generation downstream of the formyl-methionyl-leucyl-phenylalanine receptor, was investigated. PMID: 17954607
20. study found that mFPR1 is responsible for the high potency of fMIVIL and fMIFL; the ability of mFPR1 to detect bacterially derived formyl peptides indicates that this important host defense mechanism is conserved in mice PMID: 18606697

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KEGG: mmu:14293

STRING: 10090.ENSMUSP00000052894

UniGene: Mm.56951