Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.
Cell membrane, Single-pass type II membrane protein
Peptidase M28 family, M28B subfamily
High expression in the duodenum and in the jejunum brush-border membrane. Weak expression in kidney.