Recombinant Rat Glutamate carboxypeptidase 2(Folh1)

Code CSB-CF008782RA
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P70627
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Rattus norvegicus (Rat)
Sequence MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
Source in vitro E.coli expression system
Gene Names Folh1
Protein Names Recommended name: Glutamate carboxypeptidase 2 EC= 3.4.17.21 Alternative name(s): Folate hydrolase 1 Folylpoly-gamma-glutamate carboxypeptidase Short name= FGCP Glutamate carboxypeptidase II Short name= GCPII Membrane glutamate carboxyp
Expression Region 1-752
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.
Subcellular Location Cell membrane, Single-pass type II membrane protein
Protein Families Peptidase M28 family, M28B subfamily
Tissue Specificity Widely expressed throughout brain regions with highest levels in the hippocampus, dentate gyrus, priform cortex, choroid plexus of ventricles, pineal gland, anterior lobe of the pituitary gland and supraoptic nucleus. High levels also found in the cerebra
Database Links

KEGG: rno:85309

STRING: 10116.ENSRNOP00000018592

UniGene: Rn.89278

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