Recombinant Rat Lysophosphatidylcholine acyltransferase 2(Lpcat2)

Code CSB-CF013053RA
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P0C1Q3
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Rattus norvegicus (Rat)
Sequence MNRCAEAAAVAATVPGSGVGDSGLRPPMVPRQASFFPPPVPNPFVQQTRISAARRLQMILLGIILLPVRALLVGLVLLLAWPFAVISTVCCPKKLTHPISDWRRKITQPALKFLGRAMFFSMGFRVTVKGKVASPLEAPIFVVAPHSTFFDGIACVVAGLPSLVSRNENAQTPLVGRLLRALQPVLVSRVDPDSRKNTINEIKKRAMSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCVLTFCQLFTKVEVEFMPVQAPSEEERNDPVLFASRVRNLMAEALEIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGIRKHLDEYASIASSAKGGRIGASSAKGGRIGPVSDVLRQLFALFDRNNDGSIDFREYVIGLAVLCNPANTEDIIQVAFKLFDVDEDGYITEEEFCTILQASLGVPDLNVSGLFREIAQGDSVSYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPEDVQTAPSVASNKVSPESHEEGTSGKKVD
Source in vitro E.coli expression system
Gene Names Lpcat2
Protein Names Recommended name: Lysophosphatidylcholine acyltransferase 2 Short name= LPC acyltransferase 2 Short name= LPCAT-2 Short name= LysoPC acyltransferase 2 EC= 2.3.1.- Alternative name(s): 1-acylglycerophosphocholine O-acyltransferase EC= 2.
Expression Region 1-544
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. Involved in the regulation of lipid droplet number and size.
Subcellular Location Endoplasmic reticulum membrane, Single-pass type II membrane protein, Golgi apparatus membrane, Single-pass type II membrane protein, Lipid droplet
Protein Families 1-acyl-sn-glycerol-3-phosphate acyltransferase family
Database Links

STRING: 10116.ENSRNOP00000022359

UniGene: Rn.81758

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