Recombinant Rat Neuromedin-K receptor (Tacr3)

1. The different impacts of diverse long-term exercise intensities on the male pituitary-gonadal axis maybe relay by the various changes in hypothalamic Nkb and Pdyn gene expressions. PMID: 30207304
2. Results give support to the involvement of NK3 receptors in the anxiogenic-like actions of SP6-11(C-terminal), where this metabolite seems to behave as an antagonist, in a way similar to SR142801. PMID: 26851555
3. Median preoptic nucleus NK3R neurons facilitate cutaneous vasodilation, an important heat-dissipation effector. PMID: 25825817
4. data suggest that endogenous NeuroKinin B-Neurokinin 3 Receptor signalling plays a role in controlling the timing of puberty. PMID: 24863620
5. Data indicate that the suppression of the GnRH pulse generator by acute systemic stress equires hypothalamic NKB/neurokinin B (NKB) receptor (NK3R) signaling. PMID: 24708241
6. evidence that the neurokinin3 receptors (NK3-R) and their influence on acetylcholine release may represent a crucial mechanism that underlies age-related deficits in learning and memory PMID: 23983264
7. Activation of the NK3R appears to recruit multiple pathways, including acetylation, and possibly histone deactylases, histone methylases, or DNA methylases to affect chromatin structure and gene expression. PMID: 22985858
8. data provide unique evidence that KNDy neurons promote cutaneous vasodilatation and participate in the E(2) modulation of body temperature PMID: 23150555
9. Nkr3 peptide may exacerbate 6-OHDA toxicity in an in-vivo model, by modulation of N-methyl-D-aspartate receptor (Grin)1 subunit and c-Jun N-terminal kinase (JNK) pathway activities. PMID: 22762252
10. Since NK3-R is widely distributed in the CNS, the presence of NK3-R in nuclei from multiple brain regions suggests that it may broadly influence CNS gene expression in a ligand-dependent manner. PMID: 21939739
11. In response to hyperosmolarity, NK3R is transported to the nucleus of paraventricular hypothalamic neurons and associates with acetylated histone H3 and H4. PMID: 21697521
12. Data suggest that NKB/NK3R signaling in kisspeptin+ neurons in the arcuate nucleus plays a pivotal role in control of GnRH/LH secretion. NKB and NK3R mRNAs are widely expressed in the central forebrain. PMID: 21045176
13. In response to acute hyperosmotic challenge, NK3R associates with importin ss-1 which enables the nuclear transport of NK3R. PMID: 20709160
14. heterologous and homologous desensitization of NK3-R-mediated contractility is dependent upon the duration of exposure to estrogen PMID: 12390879
15. NK3 receptors had a distinct distribution in the caudal half of the solitary nucleus, suggesting a unique role in processing taste input from the posterior tongue. PMID: 15121234
16. The NK3R receptor has a role in tanscription regulation in hypotension-induced tachykinin release in the supraoptic nucleus. PMID: 15537880
17. These data suggest that NKB neurons could indirectly influence anterior pituitary function by inputs to arcuate neuroendocrine neurons, but through a receptor other than NK3R. PMID: 16025449
18. NK(3) receptors are available in cytoplasmic reserve in dopaminergic neurons, but more immediately accessible at the plasmalemmal surface of non-dopaminergic dendrites in both the SN and VTA. PMID: 17197098
19. Data provide evidence that neurokinin 3 receptors are involved in the control of the hyperlocomotor and nucleus accumbens dopamine response to cocaine, but not in cocaine-induced conditioned place preference. PMID: 17445241
20. NK3R activation contributes significantly to the systemic release of both vasopressin and oxytocin in response to osmotic and hypotensive challenges. PMID: 17522129
21. NK3R signaling in magnocellular neurons has a critical role for the release of VP and OT in response to hypotension. PMID: 18650316

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KEGG: rno:24808

STRING: 10116.ENSRNOP00000012473

UniGene: Rn.9702