Recombinant Rat Pannexin-1 (Panx1)

1. the upregulation of Pannexin1 expression may be involved in apoptosis and degeneration of neurons in the rat brain following ICH, and may contribute to subsequent cognitive dysfunction. PMID: 29484398
2. panx1 contributes to distension- or LPS-evoked ATP release into the lumen of the bladder and that luminal release can modulate voiding function. PMID: 25630792
3. Px1 channels releasing ATP have any role in the constrictor actions of alpha1-adrenoceptor activation PMID: 25637780
4. These findings indicate that Panx1 participates in urothelial mechanotransduction and signaling by providing a direct pathway for mechanically-induced ATP release and by functionally interacting with P2X7Rs PMID: 25170954
5. It was shown that angiotensin signaling in type II cells activates an inward current carried by Panx1 channels. PMID: 25172944
6. ETV4 and cAMP response elements play a role in the transcriptional regulation of Panx1 in the epididymis. PMID: 25376229
7. Panx1 up-regulation contributes to pain hypersensitivity induced by nerve injury. PMID: 25925949
8. Study found that astrocytes released ATP in response to mechanical strain, with pannexin 1 the predominant efflux pathway PMID: 24839011
9. Pannexin-1 hemichannels regulate urothelial overactivity in the bladder via activation of uracil nucleotidetide (UDP)-sensitive P2Y6 receptors. PMID: 24269631
10. These results suggest that panx1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated FFA; panx1 may play a role in hepatic inflammation by mediating an increase in extracellular ATP concentration in lipotoxic liver injury. PMID: 22972801
11. Activation of NMDA receptors during anoxia/ischemia recruits Src family kinases to open Panx1 channels, leading to sustained neuronal depolarizations. PMID: 22956847
12. pannexin 1 is expressed in smooth muscle but not in endothelium of middle cerebral arteries. PMID: 22301733
13. The results suggest that Panx1c and Panx1d may serve as dominant-negative effectors to modulate the functions of Panx1a through formation of heteromeric channels. PMID: 21907716
14. ATP, released through Px1 hemichannels, activates purinergic P2X7 receptors, resulting in the closure of Px1 hemichannels during ischemia. PMID: 21185900
15. Overexpression of pannexins 1 and 2 in pituitary cells enhanced the release of ATP. PMID: 21467198
16. indicate that the oligomerization and trafficking of Panx1 are regulated by the C-terminal domain, whereas internalization of long lived Panx1 channels occurs in a manner that is distinct from classical endocytic pathways PMID: 21659516
17. In the testis, Panx1 localized to the basal compartment of the seminiferous epithelium, while Panx3 was expressed in Leydig cells. In the ED, both Panxs were expressed in the apical region of ciliated cells. PMID: 21337450
18. Panx1 channels potentially promote arrhythmogenic activities. PMID: 21041301
19. Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other PMID: 20516070
20. Panx1 and Panx3 are coexpressed in the mammalian epidermis, and the regulation of Panx1 plays a key role in keratinocyte differentiation. PMID: 20332104
21. New insight into relationship of decreased glucose to increased seizure threshold is established through neuronal adenosine triphosphate (ATP) release via pannexin hemichannels and hippocampal adenosine A1 receptors coupled to potassium ATP channels. PMID: 20237259
22. although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules PMID: 20086016
23. the different expression patterns of pannexin 1 (Panx1) and pannexin 2 (Panx2) in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions. PMID: 14597722
24. Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons PMID: 16616526
25. Has kinetics and dynamics that make it unique to serve distinct functions separate from connexin-based channels. PMID: 18649184
26. Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions. PMID: 19009624
27. study concludes that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity PMID: 19056988
28. in contrast to macrophages and monocytes in which low intracellular K(+) has been suggested to trigger inflammasome activation, in neural cells, high extracellular K(+) activates caspase-1 probably through pannexin 1 PMID: 19416975

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KEGG: rno:315435

STRING: 10116.ENSRNOP00000013577

UniGene: Rn.204521