Recombinant Rat Vacuole membrane protein 1(Vmp1)

Code CSB-CF838715RA
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q91ZQ0
Storage Buffer Tris-based buffer,50% glycerol
Species Rattus norvegicus (Rat)
Sequence MAENGTNCDQRRGAMSKEQHNGSFTDPSSVNEKKRRDREERQNIVLWRQPLITLQYFSLE TLVVLKEWTSKLWHRQSMVVSFFLLLAALVATYYVEGAHQQYVQRIEKQFLLYAYWIGLG ILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGAISL WSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAETAQDF ASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIK MHIQKIFVIVTFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHRSEAGTAQG ENWLSWTFEKLVVAMVCYFILSIINSMAQSYAKRIQQRLNSEEKTK
Source in vitro E.coli expression system
Gene Names Vmp1
Protein Names Recommended name: Vacuole membrane protein 1 Alternative name(s): Transmembrane protein 49
Expression Region 1-406
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion (By similarity). Plays an essential role in formation of cell junctions (By similarity). Plays a role in the initial stages of the autophagic process through its interaction with BECN1.
Subcellular Location Endoplasmic reticulum-Golgi intermediate compartment membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein, Vacuole membrane, Multi-pass membrane protein, Endoplasmic reticulum
Protein Families VMP1 family
Tissue Specificity Highly expressed in intestine, kidney, ovary and placenta, moderately expressed in liver, lung, stomach, thymus, brain, and testis and slightly expressed in control thyroid and retina. Strongly expressed in pancreas (acinar cells) during acute pancreatiti
Database Links

KEGG: rno:192129

STRING: 10116.ENSRNOP00000005658

UniGene: Rn.109048

Pathway Autophagy

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