Recombinant Saccharomyces cerevisiae ADP,ATP carrier protein 2 (PET9)

1. Yeast aac2 R96H and aac2 R252G mutations are equivalent to R80H and R235G human ANT1 pathological mutations. mtDNA instability induced by aac2R96H and aac2R252G is rescued by N-acetylcysteine. PMID: 28947214
2. Mutations in yeast Aac2, equivalent to those in human Ant1 in progressive external ophthalmoplegia, cause protein misfolding. Misfolded Aac2 affects assembly & stability of multiple protein complexes in membrane, which ultimately inhibits cell growth PMID: 25833713
3. The protective role of cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p). PMID: 23220089
4. Yeast ADP/ATP carrier isoform 2: conformational dynamics and role of the RRRMMM signature sequence methionines PMID: 21868387
5. Aac2p and Sal1p may define two parallel pathways that transport a nucleotide substrate in an operational mode distinct from ADP/ATP exchange. PMID: 15238515
6. The dynamic structural change that occurs in the twisting of the second transmembrane alpha-helix of yeast mitochondrial ADP/ATP carrier (AAC) between matrix-state and cytosol-state gives new insights into the process of AAC substrate translocation. PMID: 15568812
7. the structural and functional features of the cytosolic-facing first loop (LC1) including its surrounding region PMID: 15628859
8. The functional form of Ancp is a dimer. PMID: 16274221
9. Results indicate that the matrix loop m2 of the mitochondrial ADP/ATP carrier intrudes to some extent into the inner mitochondrial membrane and may be involved in the translocation of ADP/ATP. PMID: 16331992
10. the C-terminal region of the second cytosolic loop in AAC2 changes its environment when the carrier cycles between the matrix and cytosolic state. PMID: 16962388
11. the residual transport activity in the presence of MTSES depended linearly on the amount of cysteine-less carrier. Thus, the entire transport cycle for ADP/ATP exchange is carried out by the monomer PMID: 17566106
12. yeast ADP/ATP carriers are monomeric in detergents in agreement with their hydrodynamic properties PMID: 17572439
13. the Anc2p C-terminal region is involved in nucleotide recognition, binding, and transport PMID: 18299327
14. Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport. PMID: 18431598
15. Aac2 exists in physical association with the cytochrome bc1-COX supercomplex and the TIM23 machinery PMID: 18614795
16. Pathogenic mutations likely enhance the intrinsic proton-conducting activity of adenine nucleotide translocase Aac2, which excessively uncouples the mitochondrial inner membrane thereby affecting energy transduction and mitochondrial biogenesis. PMID: 18809618
17. Tyr203 and Phe208, aromatic residues of Anc2 transmembrane domain 4 protein carrier, may play a role in nucleotide attraction and its progress through the carrier leading to a productive adenosine diphosphate/adenosine triphosphate exchange. PMID: 19086155

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KEGG: sce:YBL030C

STRING: 4932.YBL030C