Recombinant Takifugu rubripes 5-hydroxytryptamine receptor 1A-beta(htr1a-B)

Code CSB-CF523638TKY
Size Pls inquire other sizes
Source in vitro E.coli expression system

Product Details

Target Names htr1a-B
Uniprot No. O42384
Species Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Expression Region 1-416
Target Protein Sequence MEGTNNTTGWTHFDSTSNRTSKSFDEEVKLSYQVVTSFLLGALILCSIFGNACVVAAIAL ERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNRWTLGQIPCDIFISLDMLCCTSS ILHLCVIALDRYWAITEPIDYMKKRTPRRAAVLISVTWLVGFSISIPPMLIMRSQPSSMA EDRANSKQCKITQDPWYTIYSTFGAFYIPLTLMLVLYGRIFKAARFRIRRTVRKTEKKKV SDTCLALSPAMFHRKTPGDAHGKSWKRSVEPRPLPNVNGAVKHAGEGESLDIIEVQSNSR CNLPLPNTPGTVPLFENRHEKATETKRKIALARERKTVKTLGIIMGTFILCWLPFFIVAL VMPFCQESCFMPHWLKDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCHFCRA
Protein Length full length protein
Tag Info The following tags are available.
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.
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Target Data

Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior (By similarity).
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family, 5-hydroxytryptamine receptor subfamily
Database Links

KEGG: tru:101072291

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