ADM (Adrecizumab Biosimilar) Recombinant Monoclonal Antibody

1. Up-regulated mRNA and protein levels of proadrenomedullin (ProADM) during acute myocardial infarction in mice and humans. PMID: 30166452
2. ADM was an upstream molecule of HIF-1alpha/VEGF and it promoted angiogenesis through upregulating HIF-1alpha/VEGF in epithelial ovarian cancer. PMID: 28091613
3. Identifying a marker(adrenomedullin) for pancreatic cancer among high-risk patients such as new-onset diabetics might lead to the identification of a subpopulation needing to be screened in order to enable early diagnosis and treatment of a highly lethal tumor PMID: 29192743
4. High ADM expression is associated with lymph node metastasis in oral and oropharyngeal squamous cell carcinoma. PMID: 29590186
5. High expression of ADM is correlated with sunitinib-resistant renal cell carcinoma. PMID: 27556517
6. results indicate a novel function of adrenomedullin (ADM) in pancreatic ductal adenocarcinoma (PDAC), and suggest ADM is a promising target in the treatment of PDAC. PMID: 27391260
7. Report an association of elevated ProADM blood levels and 10-year all-cause mortality in a primary care cohort with respiratory tract infections. PMID: 28676115
8. These results indicate that elevated ADM may be involved in the etiology of schizophrenia through the regulation of heat shock protein signaling. PMID: 27776076
9. our results pointed towards two MR-pro-ADM threshold values that appear to predict with a good degree of accuracy the patient's need for non-invasive mechanical ventilation, endotracheal intubation, or intensive care. This aspect, however, deserves further investigation PMID: 29161297
10. promotes the proliferation and inhibits apoptosis of dental pulp stem cells PMID: 27475098
11. MR-proADM but not copeptin was significantly associated with prognosis of COPD exacerbations at 30 days. PMID: 28408815
12. Findings indicate the importance of cancer-associated fibroblasts (CAFs)-derived adrenomedullin (AM) pathway in growth of breast carcinoma and in neovascularization by supplying and amplifying signals that are essential for pathologic angiogenesis. PMID: 28178651
13. This study indicates that in children with community-acquired pneumonia, sTREM-1, Midregional-proANP, and Midregional-proADM blood levels have poor abilities to differentiate bacterial from viral diseases or to identify severe cases. PMID: 27846213
14. Admission MR-proADM concentrations provide strong prognostic information in patients with acute HF, but modest diagnostic information in patients with acute dyspnea. PMID: 28065681
15. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. PMID: 27553639
16. SHH acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells . PMID: 27246849
17. MR-proADM showed a significant association with BP reduction after 6 months PMID: 27153479
18. Elevated plasma level of MR-proADM, determined 24 h after diagnosis of Cardiogenic shock could be a predictor of in-hospital mortality in patients with acute myocardial infarction complicated by CS. PMID: 27788594
19. Our findings showed that adrenomedullin expression increased in progression from benign endometrium to endometrial intraepithelial neoplasia and type-1 adenocarcinoma PMID: 26972419
20. The levels of IL-8, IL-12, and adrenomedullin may be good indicators of embryo and oocyte quality in endometriosis patients undergoing IVF. PMID: 27491770
21. Evidence show that ADM could affect the growth and differentiation of leukemia cells by modulating RAMPs/CRLR expression, PI3K/Akt cascade and the ERK/MAPK signaling pathway. PMID: 26847772
22. A panel of three biomarkers (MR-proANP, PCT, and MR-proADM) in patients presenting to the emergency unit with acute dyspnea provides information about the probability of acute heart failure, nonsurvival, and pneumonia. PMID: 26748496
23. Higher levels of Proadrenomedullin are associated with Primary Graft Dysfunction and Mortality Following Lung Transplantation. PMID: 26461449
24. conclusion supplementation with selenium and coenzyme Q10 during four years resulted in less concentration of both copeptin and MR-proADM PMID: 26662217
25. High Adrenomedullin expression is associated with Malignant Pleural Mesothelioma. PMID: 26762744
26. Among adrenomedullin, CRP, and PCT, procalcitonin demonstrates the highest correlation with the severity of infection. PMID: 26271020
27. we found significantly lower plasma MR-proADM levels in patients with elevated anxiety scores PMID: 26342564
28. AM is expressed by peritoneal mesothelial cells and actively amidated in the abdominal cavity of patients undergoing peritoneal dialysis. PMID: 23564381
29. Results suggest that ADM plays an important role in intrahepatic cholangiocellular carcinoma metastasis, and that ADM signaling of epithelial-mesenchymal transition may represent a valuable therapeutic target in cancer patients. PMID: 26043778
30. targeting of the ADM/ADM acceptors/ERK1/2/Bcl-2 pathway may provide a potential strategy through which to induce the apoptosis of osteosarcoma cells. PMID: 26035796
31. In addition to its role in the complement system, complement factor H has an another role, as a binding protein for the regulatory peptide adrenomedullin. (Review) PMID: 26597206
32. Proadrenomedullin was increased in complicated vs. uncomplicated community acquired pediatric pneumonia. PMID: 26286191
33. AM expression gets rapidly activated by hypoxia through a HIF-1alpha mediated mechanism, thus characterizing AM as a major survival factor for tumour cells PMID: 25475159
34. tested the hypothesis that AM-deficient fetal primary pulmonary microvascular endothelial cells (HPMEC) will have increased oxidative stress, inflammation, and cytotoxicity compared to AM-sufficient HPMEC upon exposure to hyperoxia PMID: 26196743
35. Diabetes status had no impact on midregional proadrenomedullin concentrations or in the predictive value of heart failure. PMID: 25528198
36. Allelic variation in ADM and increased plasma MR-proADM are associated with susceptibility to progression of diabetic kidney disease in type 2 diabetic patients. PMID: 25948679
37. Adrenomedullin potentiates osteolytic responses in bone to metastatic breast cancer cells. PMID: 25439669
38. Plasma adrenomedullin level is enhanced in nasopharyngeal carcinoma.Adrenomedullin is correlated with stage progression and with long-term survival of nasopharyngeal carcinoma patients. PMID: 25433141
39. There was a significant increase in plasma AM, VCAM-1, and ICAM-1, while a significant decrease in plasma basic-Fibroblast growth factor (b-FGF) in diabetic patients with peripheral vascular disease (p < 0.05). PMID: 25287126
40. the ADM gene has a role in the modulation of peripheral vascular tone PMID: 25053723
41. plasma mid-regional pro-adrenomedullin helps predict pre-eclampsia PMID: 24853905
42. ADM genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood. PMID: 25313554
43. higher plasma adrenomedullin levels on presentation are associated with clinical severity and worse outcomes in patients with acute spontaneous aneurysmal subarachnoid hemorrhage PMID: 25009125
44. midregional pro-adrenomedullin plasma concentrations blunted in severe preeclampsia PMID: 25043691
45. adrenomedullin acts as a critical promoter of cell cycle progression in hepatocellular carcinoma cells PMID: 24927229
46. Elevated plasma adrenomedullin concentration is highly associated with 3-month clinical outcomes and early neurological deterioration of patients with acute intracerebral hemorrhage. PMID: 24457114
47. Results demonstrate a novel function of HIFs in regulating ADM expression by enhancing its pre-mRNA splicing. PMID: 24523299
48. N-terminal PEGylated Adrenomedullin stimulated cAMP production in vitro, showing lessened acute hypotensive action and a prolonged plasma half-life in comparison with native Adrenomedullin peptide in vivo. PMID: 24874704
49. the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus PMID: 24831942
50. The correlation of ADM expression level with the measures of stroke severity implicates ADM -a potential blood bio-marker in studies of ischemic stroke. PMID: 23968191

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HGNC: 259

OMIM: 103275

KEGG: hsa:133

STRING: 9606.ENSP00000278175

UniGene: Hs.441047