ADM

ADM corresponds to adrenomedullin, also known as AM. This protein is a multifunctional peptide with diverse physiological roles. It exerts its effects primarily through binding to specific receptors, such as the calcitonin receptor - like receptor (CLR) in combination with receptor - activity - modifying proteins (RAMPs). It is involved in the cAMP - dependent signaling pathway.
ADM has been linked to various diseases, including hypertension, heart failure, and sepsis. In drug development, efforts are underway to design analogs or antagonists targeting the ADM - related signaling pathways. These potential drugs aim to regulate the biological activities of ADM for better treatment of the associated diseases.