AMHR2 (Murlentamab Biosimilar) Recombinant Monoclonal Antibody

1. AMHR2 single nucleotide polymorphism is not associated with Endometriosis-associated infertility. PMID: 28831646
2. AMHRII 1749C > T and -482A > G genetic variants are associated with the ovarian response to standard gonadotropin stimulation, affecting mainly the follicular growth in IVF. PMID: 26933946
3. a result of VEGF misregulation, AMHR2 overexpression increases AMH binding, which may attenuate follicular or oocyte maturation. PMID: 27109000
4. -482A > G genotype not associated with estradiol levels, ovarian parameters, menstrual cycle length, or pregnancy outcomes in healthy Singapore women PMID: 26633196
5. A significant subset of GnRH neurons express the AMH receptor. PMID: 26753790
6. A significant portion of AMHRII was missing most of its extracellular domain (ECD) and was unfolded and retained in the endoplasmic reticulum. PMID: 25663701
7. study demonstrated for the first time that human placenta and fetal membranes express and co-localize Anti-Mullerian hormone(AMH) and Anti-Mullerian hormone Receptor II PMID: 25972076
8. AMHR2 rs11170555 and rs3741664 were positively associated with AMH, estradiol and FSH levels. PMID: 25790842
9. Data indicate that Muellerian inhibiting substance type II receptor (MISRII) is a promising target for the control of ovarian granulosa cell tumors (GCT) and epithelial ovarian cancers (EOC). PMID: 25517316
10. The possible involvement of AMHRII -482 A>G polymorphism on the malfunction of follicular development in Japanese women. PMID: 24271023
11. Antimullerian hormone receptor expression is increased in endometrium from patients with endometriosis. PMID: 24613539
12. Within primary ovarian insufficiency population, the AMH Ile(49)Ser and the AMHR2 -482A>G polymorphisms were not associated with age at the time of POI and PMID: 24146295
13. The role of the AMHR2 -482 A>G gene polymorphism in the pathogenesis of polycystic ovary syndrome was suggested by the association of the variant with risk. PMID: 23969185
14. likely molecular etiology was found in eight patients with persistent Mullerian duct syndrome. Four mutations in AMH and two in AMHR2 were identified. Three of them are novel mutations, c.556-2A>G, and p.Arg502Leu in AMH; and p.Gly323Ser in AMHR2. PMID: 23295284
15. Data suggest that up-regulation of AMHR2 and AMH expression in luteal granulosa cells of anovulatory women with polycystic ovary syndrome is due to rising levels of luteinizing hormone (LH) and/or reversal of down-regulation by LH. PMID: 23321213
16. The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained beta-catenin signaling. PMID: 22962306
17. the diversity of clinical symptoms within sibship and lack of correlation between development of Mullerian derivatives and severity of molecular defects suggest highly variable penetrance of abnormal alleles PMID: 22584735
18. Association studies of common variants of AMHRII suggests that antimullerian hormone may regulate the primordial graafian follicle recruitment. PMID: 20362961
19. Review. The role of AMHR2 in gonadal development and its mutation in the persistent Mullerian duct syndrome is discussed. PMID: 12462075
20. binding domains recognized by a monoclonal antibody and the natural ligand PMID: 14750901
21. The observed association of the AMHR2 -482 A > G polymorphism with natural age at menopause suggests a role for AMH signaling in the usage of the primordial follicle pool in women. PMID: 17636279
22. MISIIR is highly expressed by a wide variety of gynecologic cancers, including cancers currently without effective systemic therapies. PMID: 17988723
23. Reduced AMH receptor type 2 is associated with Leydig cell tumours in multiple endocrine neoplasia type 1 PMID: 18310289
24. Non-epithelial malignant ovarian tumors showed stronger expression of anti-Mullerian hormone receptor type II than that of epithelial tumors. PMID: 19424576
25. Mutations of AMHR2 found in persistent Mullerian duct syndrome affect its ligand binding and cellular transport. PMID: 19457927
26. interacts with Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. PMID: 11588147

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HGNC: 465

OMIM: 261550

KEGG: hsa:269

STRING: 9606.ENSP00000257863

UniGene: Hs.659889