Name: CLC (ARGX-118 Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA2267MB1HU

Product Details

Uniprot No.

Q05315

Target Names

CLC

Alternative Names

CLC antibody; LGALS10 antibody; LGALS10A antibody; Galectin-10 antibody; Gal-10 antibody; Charcot-Leyden crystal protein antibody; CLC antibody; Eosinophil lysophospholipase antibody; Lysolecithin acylhydrolase antibody

Species Reactivity

Human

Immunogen

Recombinant Human CLC protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to ARGX-118, targeting the Charcot-Leyden crystal (CLC) protein, also known as galectin-10. CLC is predominantly expressed in eosinophils and basophils, where it constitutes a significant portion of cellular protein content. Upon degranulation of these cells, CLC is released into tissues and can crystallize, forming characteristic bipyramidal crystals that serve as hallmarks of eosinophilic inflammation. This protein plays a crucial role in type 2 inflammatory responses and has been implicated in various allergic and eosinophilic disorders, including asthma, chronic rhinosinusitis, eosinophilic esophagitis, and hypereosinophilic syndromes.

ARGX-118 represents a therapeutic antibody approach aimed at neutralizing CLC to modulate eosinophil-driven inflammation. As a research-grade biosimilar, this antibody provides investigators with a valuable tool for studying CLC biology, eosinophil function, and the pathophysiology of type 2 inflammatory diseases. It supports investigations into novel therapeutic strategies for conditions characterized by aberrant eosinophil activation and tissue infiltration.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).

Gene References into Functions

findings show that galectin-10 functions as a T cell-suppressive molecule in eosinophils PMID: 28515279
The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation. PMID: 22880030
CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents PMID: 20858065
Genetic variation in Charcot-Leyden crystal protein was found to be associated with allergic rhinitis PMID: 19650845
downregulated significantly in acute myeloid leukemia patients whose white blood cell count was higher than 100 x 10(9)/L cells PMID: 12031912
Changes in the expressions of galectin-10 are potentially important for myeloid cell differentiation into specific lineages. PMID: 12714580
The five genes, and three of the encoded proteins, were shown differentially expressed between a group of keratoconus patients and a reference group using different techniques PMID: 16015083
Downregulated in whole blood of infants hospitalised with respiratory syncytial virus (RSV), subtype B, bronchiolitis. PMID: 17166282
expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25(+) Treg cells. PMID: 17502455
Data show that galectin-10 expression was related to the histological grade and with the number of eosinophils in the lesion. PMID: 19758173

Hide All

Subcellular Location

Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.

Tissue Specificity

Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with

Database Links

HGNC: 2014

OMIM: 153310

KEGG: hsa:1178

STRING: 9606.ENSP00000221804

UniGene: Hs.889

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Code	CSB-RA2267MB1HU
Size	US$9799
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CLC (ARGX-118 Biosimilar) Recombinant Monoclonal Antibody

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Target Background