CLC Antibody

Datasheet

Code	CSB-PA22679A0Rb
Size	US$166
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Image	IHC image of CSB-PA22679A0Rb diluted at 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA22679A0Rb diluted at 1:400 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of A549 cells with CSB-PA22679A0Rb at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CLC Polyclonal antibody

Uniprot No.

Q05315

Target Names

CLC

Alternative Names

BSF3 antibody; Charcot Leyden crystal protein antibody; Charcot-Leyden crystal protein antibody; CLC antibody; EC 3.1.1.5 antibody; Eosinophil lysophospholipase antibody; Gal-10 antibody; Galectin-10 antibody; LGALS10 antibody; LGALS10A antibody; LPPL HUMAN antibody; LPPL_HUMAN antibody; Lysolecithin acylhydrolase antibody; MGC149659 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Galectin-10 protein (2-142AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CLC Antibody (Product code: CSB-PA22679A0Rb) is Non-conjugated. For CLC Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA22679B0Rb	CLC Antibody, HRP conjugated	ELISA
FITC	CSB-PA22679C0Rb	CLC Antibody, FITC conjugated
Biotin	CSB-PA22679D0Rb	CLC Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).

Gene References into Functions

findings show that galectin-10 functions as a T cell-suppressive molecule in eosinophils PMID: 28515279
The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation. PMID: 22880030
CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents PMID: 20858065
Genetic variation in Charcot-Leyden crystal protein was found to be associated with allergic rhinitis PMID: 19650845
downregulated significantly in acute myeloid leukemia patients whose white blood cell count was higher than 100 x 10(9)/L cells PMID: 12031912
Changes in the expressions of galectin-10 are potentially important for myeloid cell differentiation into specific lineages. PMID: 12714580
The five genes, and three of the encoded proteins, were shown differentially expressed between a group of keratoconus patients and a reference group using different techniques PMID: 16015083
Downregulated in whole blood of infants hospitalised with respiratory syncytial virus (RSV), subtype B, bronchiolitis. PMID: 17166282
expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25(+) Treg cells. PMID: 17502455
Data show that galectin-10 expression was related to the histological grade and with the number of eosinophils in the lesion. PMID: 19758173

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Subcellular Location

Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.

Tissue Specificity

Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with

Database Links

HGNC: 2014

OMIM: 153310

KEGG: hsa:1178

STRING: 9606.ENSP00000221804

UniGene: Hs.889

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