CLC

CLC refers to the Chloride Intracellular Channel Protein family. These proteins, also commonly known as CLICs, play crucial roles in cellular functions. Their mechanism involves regulating chloride ion transport across cell membranes, which is essential for maintaining cell volume, pH balance, and electrical excitability. They are associated with the Wnt and TGF - β signaling pathways.
Dysregulation of CLC proteins is linked to diseases such as cancer and neurodegenerative disorders. In drug development, researchers are exploring inhibitors and activators of these proteins to target these diseases. Some promising compounds are in pre - clinical trials, aiming to modulate CLC - related pathways for better therapeutic outcomes.