Name: CLEC6A (BDC-3042 Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA738603MB1HU

Product Details

Uniprot No.

Q6EIG7

Target Names

CLEC6A

Alternative Names

BDC3042 research-grade biosimilar; BDC 3042 research-grade biosimilar ;CLEC6A antibody; CLECSF10 antibody; DECTIN2 antibody; C-type lectin domain family 6 member A antibody; C-type lectin superfamily member 10 antibody; Dendritic cell-associated C-type lectin 2 antibody; DC-associated C-type lectin 2 antibody; Dectin-2 antibody

Species Reactivity

Human

Immunogen

Recombinant Human CLEC6A protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to BDC-3042, targeting CLEC6A (C-type lectin domain family 6 member A), also known as Dectin-2. CLEC6A is a pattern recognition receptor primarily expressed on myeloid cells, including dendritic cells and macrophages, where it plays a critical role in innate immune responses. This receptor recognizes fungal cell wall components and certain endogenous ligands, triggering inflammatory signaling pathways through Syk kinase activation. CLEC6A is implicated in various pathological conditions, including fungal infections, inflammatory diseases, and has been associated with immune responses in cancer and autoimmune disorders.

The reference antibody BDC-3042 has been utilized in immunological research to investigate CLEC6A expression patterns and functional roles in immune cell populations. This biosimilar provides researchers with a reliable tool for studying CLEC6A-mediated immune recognition, antifungal immunity, and inflammatory signaling mechanisms. It supports investigations into innate immune regulation, host-pathogen interactions, and the development of therapeutic strategies targeting CLEC6A-dependent pathways in infectious and inflammatory diseases.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.

Gene References into Functions

functions in Kupffer cells to mediate the uptake and clearance of cancer cells PMID: 27872290
Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin domain containing 6A) PMID: 28652405
these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 responses through interaction with Dectin-2. PMID: 27358401
This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis. PMID: 26129889
human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2 PMID: 25659141
our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation. PMID: 24129160
The Dectin-2 possess a single extracellular conserved C-type lectin-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules. PMID: 23606632
human DECTIN-2 has a role in innate immunity PMID: 15810886

Hide All

Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Tissue Specificity

Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.

Database Links

HGNC: 14556

OMIM: 613579

KEGG: hsa:93978

STRING: 9606.ENSP00000371505

UniGene: Hs.591147

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：
Please enter the characters shown. Click the image to refresh if unclear.

Code	CSB-RA738603MB1HU
Size	US$9799
	Order now
Have Questions?	Leave a Message or Start an on-line Chat

CLEC6A (BDC-3042 Biosimilar) Recombinant Monoclonal Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background