CLEC6A

CLEC6A encodes the C-type lectin domain containing 6A protein, also known as Dectin-2. Dectin-2 is a pattern - recognition receptor mainly expressed on myeloid cells. It recognizes carbohydrate structures on pathogens, triggering intracellular signaling cascades. This protein is involved in the Syk - CARD9 - NF - κB pathway, which is crucial for innate immune responses.
Dysregulation of CLEC6A has been linked to various infectious diseases and autoimmune disorders. Scientists are exploring drugs that target CLEC6A to modulate immune responses. Some small - molecule inhibitors are in pre - clinical studies, aiming to treat diseases related to abnormal immune activation.