FZD7 (Vantictumab Biosimilar) Recombinant Monoclonal Antibody

1. miR-504-meidated FZD7/Wnt/beta-catenin signaling pathway plays an important role in hepatocellular carcinoma development. PMID: 30142536
2. High FZD7 expression is associated with Glioma. PMID: 30010402
3. SOX8 bounds to the promoter region of FZD7 and induces the FZD7-mediated activation of the Wnt/beta-catenin pathway and confers chemoresistance and stemness properties and mediates epithelial mesenchymal transition in chemoresistant tongue squamous cell carcinoma. PMID: 29071717
4. Frizzled 7 and phosphatidylinositol 4,5-diphosphate binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signaling. PMID: 27386966
5. FZD7 may promote glioma cell proliferation via upregulation of TAZ. PMID: 27852064
6. The miR-485-5p/FZD7 axis may provide novel insights into understanding the molecular pathogenesis of melanoma. PMID: 28364602
7. FZD7 and IDH1 were assessed by immunohistochemistry in tissue microarrays. PMID: 27409829
8. FZD7 transmits non-canonical Wnt signaling by interacting Wnt5A in the regulation of extracellular matrix expression. PMID: 28736081
9. Silencing of FZD7 inhibits the growth, migration and invasion of esophageal squamous cell carcinoma cells. Silencing of FZD7 impedes the activation of Wnt signaling. PMID: 28669726
10. Taken together, our study suggests that miR-542-3p inhibits HCC cell growth by targeting FZD7 and inhibiting Wnt signaling pathway. The decreased miR-542-3p expression may also contribute to the progression of HCC and may represent a novel molecular therapeutic target for HCC. PMID: 27815069
11. Findings suggest that FZD7, involved in canonical Wnt signaling pathway, plays a critical role in mediating BMSCs-dependent protection of CML cells. PMID: 26716419
12. Results found that FZD7 was highly upregulated by H. pylori infection and was associated with H. pylori infection-induced cell proliferation. PMID: 26780940
13. This paper suggests that Fzd7 may act as one of the molecules that take part in the course of renal cell carcinoma formation PMID: 26243397
14. FZD7 is a unique and nonredundant target of NOTCH3 in human breast epithelial cells. PMID: 26847503
15. SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF. Our results suggested that SNX27 interacts with Frizzled receptors to regulate the endocytosis and stability of Fzds PMID: 26744382
16. Data show that cell proliferation and tumor growth decreased significantly after transfection with the plasmid frizzled 7 protein (FZD7)-Shiga-like toxin I (Stx1). PMID: 26498690
17. FZD7 activated JNK in melanoma cell lines in vitro and the expression of a dominant negative JNK suppressed metastasis formation in vivo, suggesting that FZD7 may promote metastatic growth of melanoma cells via activation of JNK PMID: 26808375
18. conclusion, our study suggests that miR-613 functions as a tumor suppressor, partially through targeting Fzd7, and is a potential therapeutic target for prostate cancer. PMID: 26703210
19. High FZD7 expression is associated with cell migration, invasion, and epithelial-mesenchymal transition of cervical cancer. PMID: 25740178
20. High expression of FZD7 is associated with cervical cancer. PMID: 25976503
21. Frizzled 7 expression is positively regulated by SIRT1 and beta-catenin in breast cancer cells. PMID: 24897117
22. Expression of FZD7 was inversely correlated with miR-199a in both hepatocellular carcinoma tissues and cells and over-expression of miR-199a significantly down-regulates the expression of genes downstream of FZD7. PMID: 25313882
23. Knockdown of FZD7 in Stem-A subtype of ovarian cancer cells showed reduced cell proliferation with an increase in the G0/G1 sub-population. PMID: 25032869
24. finding suggests that Wnt signaling is one of the factors of LSC niche, and Fz7 helps to maintain the undifferentiated state of LSCs. PMID: 24170316
25. Data indicate that Wnt receptor Fzd7-dependent enhancement of Wnt signalling by DeltaNp63 governs tumour-initiating activity of the basal subtype of breast cancer. PMID: 25241036
26. results demonstrate that FZD7 encodes a regulator of the pluripotent state and that hESCs require endogenous WNT/beta-catenin signaling through FZD7 to maintain an undifferentiated phenotype PMID: 24474766
27. Our findings suggest that FZD7-involved canonical Wnt signaling pathway is essential for tumorigenesis of TNBC. PMID: 21532620
28. Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment. PMID: 19655379
29. FZD7 plays a pivotal role in morphology transitions that are associated with colon tumor initiation and progression. PMID: 15901282
30. During development, FZD7 orchestrates either migratory or epithelialization which implicate similar functional diversity for FZD7 during colorectal cancer devvelopment. PMID: 17016432
31. These findings pinpoint calpain-1 as a regulator of Frizzled-7 turnover at the plasma membrane and reveal a link between Frizzled-7 cleavage and its activity. PMID: 17716656
32. Syntenin stimulates c-jun phosphorylation and modulates Frizzled 7 signaling, in particular the PKCalpha/CDC42 noncanonical Wnt signaling cascade. PMID: 18256285
33. FZD7-siRNA may be used as a therapeutic reagent for colorectal cancer. PMID: 18592008
34. findings identify the WNT receptor FZD7 as a novel ES cell-specific surface antigen with a likely important role in the maintenance of ES cell self-renewal capacity PMID: 18681827
35. FZD7 may be involved in enhancement of survival, invasion and metastatic capabilities of colon cancer cells through non-canonical Wnt signalling pathways as well as the canonical pathway. PMID: 19773752

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HGNC: 4045

OMIM: 603410

KEGG: hsa:8324

STRING: 9606.ENSP00000286201

UniGene: Hs.173859