IFNAR1 (Anifrolumab-FNIA Biosimilar) Recombinant Monoclonal Antibody

1. IFNAR1 signaling underlies an increased risk of tuberculosis in humans and reveals a function for the IFNAR1 inter-domain region in cytokine-cytokine receptor interaction and signal transduction. PMID: 29311663
2. HCV-1b core protein-induced miR-93-5p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the miR-93-5p-IFNAR1 axis regulates STAT1 phosphorylation. PMID: 29375208
3. Relapsing-remitting multiple sclerosis patients manifested a statistically higher expression level of IFNAR1 than their normal counterparts. PMID: 28282804
4. cellular kinase, casein kinase 1alpha (CK1alpha), is crucial for IAV HA-induced degradation of both IFNGR1 and IFNAR1. PMID: 29343571
5. The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
6. Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer. PMID: 28842285
7. Here, we review the current knowledge on the main strategies that human pathogenic flaviviruses utilize to escape both type I IFN induction and effector pathways. [review] PMID: 28576494
8. the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy. PMID: 27346865
9. Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche. PMID: 28196594
10. These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication. PMID: 27569280
11. this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo in Estonian patients PMID: 26429320
12. A small proportion of both pancreatic and periampullary tumors showed a strong expression of the IFNAR-1. PMID: 25072284
13. rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations. PMID: 26679744
14. Genetic polymorphisms of the promoter of INFAR gene represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection. PMID: 25939635
15. data illustrate a lipid G-protein coupled receptor (GPCR)-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 signaling PMID: 26787880
16. Data suggest IFNA2 (interferon, alpha 2) binding to extracellular domain of IFNAR1 or IFNAR2 promotes proximity between intracellular domains; signaling depends on duration of activation/affinity of binding rather than specific conformational changes. PMID: 26679999
17. These findings suggest that influenza A virus hemagglutinin causes IFNAR1 degradation, which in turn helps the virus escape the powerful innate immune system. PMID: 26676772
18. Prolidase was required for IFNAR1 maturation and accumulation, activation of IFNbeta-stimulated gene induction, and IFN-I-dependent viral control. PMID: 26159719
19. IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients PMID: 25675103
20. The expression of IFNAR1, IFNgammaR1 and ribovarin transporters were significantly impaired in chronic liver disease and cirrhotic livers. PMID: 25265476
21. Results show that SNPs in IFNAR1 and IFNG were risk factors for malaria in Indian population. PMID: 25445652
22. sequence variants of both the IFNAR1-17470 and IL-10-592 genes were correlated with susceptibility to chronic hepatitis B. PMID: 25501140
23. Dimerization of IFNAR1 and IFNAR2 and the limiting role of IFNAR1 binding affinity in complex assembly is modulated by USP18. PMID: 26008745
24. The crystal structure of a receptor-binding fragment of human TYK2, encompassing the FERM and SH2 domains, in complex with peptide motif from the interferon-alpha receptor chain 1 (IFNAR1) is presented. PMID: 24704786
25. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection. PMID: 23663046
26. [review] The type I interferon system has an important role in the pathogenesis of Sjogren's syndrome. PMID: 23201923
27. Results identified genetic variants in interferon genes that influence melanoma progression and survival with modulation of effect due to treatment status. PMID: 23209811
28. PTP1B is a specific regulator of IFNAR1 endocytosis. PMID: 23129613
29. common genetic changes in IFNAR1 may influence HCC risk, likely through miR-1231-mediated regulation. PMID: 22824466
30. These new findings reveal distinct and overlapping signaling mechanisms used by B-cell antigen receptor and IFNAR in the regulation of TLR7 tolerance and activation. PMID: 22786773
31. Systemic lupus erythematosus patients are found to have the highest serum type I IFN activity; in contrast, the untreated relapsing-remitting multiple sclerosis population has the lowest levels of endogenous IFN-alpha/beta activity. PMID: 22036215
32. 2A protease encoded by EV71 as an antagonist of IFNB1 and the protease activity is required for reducing IFNAR1 levels. PMID: 22258259
33. HBX expression downregulates type I IFN receptor, leading to disturbance of extracellular type I IFN signaling. PMID: 22218495
34. CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
35. Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes. PMID: 22162633
36. Early progenitors and mature megakaryocytes, but not platelets, express functional IFNAR and synthetize/release IFN-beta, revealing not only that megakaryo/thrombopoiesis regulation by IFN-I is associated with a specific interaction with its receptor PMID: 22136495
37. IFNalphaR is dispensable on responding CD4+ T cells. Cells derived from transgenic bone marrow are sufficient to restore IFNalphaR-dependent pathways in IFNalphaR-deficient mice. PMID: 22156349
38. Tyrosine phosphorylation of PKD2 is required for IFNalpha-stimulated activation of this kinase as well as for efficient serine phosphorylation and degradation of IFNAR1 and ensuing restriction of the extent of cellular responses to IFNalpha. PMID: 21865166
39. In cells exposed to VEGF, phosphorylation-dependent degradation of IFNAR1 leads to an inhibition of type 1 IFN signaling and is required for efficient VEGF-stimulated angiogenesis. PMID: 21832278
40. The results of this study suggest that expression of cell surface IFNAR1 is critical for the response of hepatitis C virus to exogenous interferon alpha. PMID: 21756311
41. These data demonstrate that West Nile virus infection results in a reduction of IFNAR1 protein through a non-canonical protein degradation pathway, and may participate in the inhibition of the interferon response. PMID: 21830897
42. activation of p38 kinase in response to pathogen-recognition receptors stimulation results in a series of phosphorylation events within the IFNAR1 chain of the Type I IFN receptor PMID: 21695243
43. The consequent effect of SOCS1 inhibition of Tyk2 not only results in a reduced IFN response because of inhibition of Tyk2 kinase-mediated STAT signaling but also negatively impacts IFNAR1 surface expression, which is stabilized by Tyk2. PMID: 21757742
44. A low number of receptors suffices for antiviral response and is thus a robust feature common to all cells. Conversely, a high number of receptors is required for antiproliferative activity, which allows for fine-tuning on a single-cell level. PMID: 21690295
45. an important role of p38 kinase in the ligand-independent stimulation of IFNAR1 ubiquitination and degradation PMID: 21540188
46. Expression and kinase activity of PKD2 are required for the ligand-inducible stimulation of IFNAR1 ubiquitination and endocytosis and for accelerated proteolytic turnover of IFNAR1. PMID: 21173164
47. Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. PMID: 19957332
48. These results suggest that a combination of serum soluble interferon-alpha/beta receptor and high-sensitivity-CRP thresholds may be more reliable diagnostic parameter for gastrointestinal and hepatobiliary-pancreatic cancer. PMID: 19879773
49. The expression of interferon-alpha receptor in liver tissues in patients with chronic hepatitis B correlates well with the pathological grading and alanine aminotransferase level. PMID: 19220955
50. The 3a protein was found to induce serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and to increase IFNAR1 ubiquitination. PMID: 20020050

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HGNC: 5432

OMIM: 107450

KEGG: hsa:3454

STRING: 9606.ENSP00000270139

UniGene: Hs.529400