IL17RA (Brodalumab Biosimilar) Recombinant Monoclonal Antibody

1. The SNP rs4819554 in the promoter region of IL17RA significantly influences the response to anti-TNF drugs at week 12. PMID: 27670766
2. Combination of polymorphisms in the NOD2, IL17RA, EPHA2 and KALRN genes could play a significant role in the development of sarcoidosis by maintaining a chronic pro-inflammatory status in macrophages PMID: 29554915
3. The data connect increased interleukin (IL)-17A/IL-17RA signaling in autism spectrum disorder patients with enhanced oxidative inflammation in monocytes. PMID: 28935156
4. IL-17RA is essential for mucocutaneous immunity to Candida and Staphylococcus, but otherwise largely redundant PMID: 27930337
5. Here, we discuss the latest discoveries on the role of the IL-17A/IL-17RA axis in driving host pulmonary defence and immunopathology. PMID: 27033174
6. High IL-17RA expression is associated with prostate cancer. PMID: 26871944
7. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling. PMID: 28298222
8. cyanidin specifically recognizes an IL-17A binding site in the IL-17A receptor subunit (IL-17RA) and inhibits the IL-17A/IL-17RA interaction. PMID: 28223414
9. SNP rs4819554 in promoter is associated with functional severity of ankylosing spondylitis PMID: 27415816
10. It has been shown that IL-17 can be produced by enteroendocrine chromogranin A-positive cells as well as by goblet cells in the human colon. PMID: 27660002
11. Results suggest that IL-17-IL-17R interaction in GSCs induces an autocrine/paracrine cytokine feedback loop, which may provide an important signaling component for maintenance/self-renewal of GSCs. PMID: 26755664
12. High IL-17RA expression is associated with Intrahepatic Cholangiocarcinoma. PMID: 26228109
13. Identified the IL17RA rs4819554 SNP as a risk factor for psoriasis. PMID: 26347322
14. IL-17 receptor A and adenosine deaminase 2 deficiency due to deletion mutations was found in siblings with chronic mucocutaneous candidiasis and chronic systemic inflammation. PMID: 26607704
15. In vitro, CSE stimulation significantly increased IL-17F and IL-17R in 16HBE (2.5%) and A549 (5%) while IL-17A and IL-17F in PBMC (10%). IL-17A and CSE stimulation, rather than CSE or rhIL-17A alone, increased proliferation in 16HBE and apoptosis in A549 PMID: 26198032
16. The data indicate that the genetic variants of rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA may not play a role in the pathogenesis of preeclampsia in Chinese Han women. PMID: 26451724
17. IL17F and IL17RA polymorphisms modulate susceptibility to cerebral malaria(CM) and provide evidence that IL-17F protects against CM. PMID: 26667835
18. Increased expression of IL-17RA plays an important role in gastric cancer progression, migration and prognosis. PMID: 26261590
19. Both genetic variants of IL-17R (rs882643 and rs2241049) were associated with PGD. This confirms a genetic predisposition toward PGD and suggests a role of IL-17 in driving neutrophilia in PGD. PMID: 25935436
20. The presence of IL7R polymorphisms seems to be related to severe liver disease in HIV/hepatitis c virus coinfected patients. PMID: 26123260
21. expression of immunoreactivity for IL-17A, IL-17RA, IL-17E, and IL-17F was significantly elevated in prostatic tissue from benign prostatic hyperplasia and prostate cancer compared with that in controls PMID: 26356122
22. genetic polymorphism is associated with a reduced renal filtration rate, and with the risk of developing end stage renal disease in healthy elderly from Spain PMID: 25636567
23. IL17RA polymorphisms, but not those of IL17, can influence both the development and the bilaterality of papillary thyroid carcinoma PMID: 25484349
24. IL-17R was almost exclusively expressed by endothelial cells, not by myeloma cells in the masses of skeletal extramedullary disease patients. PMID: 24916639
25. Interleukin-17 receptor A crystal structure shows that the downstream motif of IL-17RA SEFIR together with helix alpha C could provide a composite ligand-binding surface for recruiting Act1 during IL-17 signaling. PMID: 24816115
26. IL17-dependent retinal degeneration in a mouse model of focal retinal degeneration can be prevented by gene therapy with adeno-associated virus vector encoding soluble IL17 receptor PMID: 24780906
27. Whereas no association was found between the alternative splicing SNP, rs6897932, and multiple sclerosis, a significant link was found between the promoter single nucleotide polymorphism, rs11567685, and the disease. PMID: 24166352
28. Genetic variation in interleukin-17 receptor A is functionally associated with chronic rejection after lung transplantation. PMID: 24263024
29. Data show that the interleukin (IL)-17 receptor IL-17RA variant is generated by spliced out of exon 11 encoding the transmembrane region in a variety of tissues. PMID: 24084331
30. The increased IL-25 levels in plasma and the expression of IL-17RA and IL-17RB on eosinophils in allergic asthma patients suggests that IL-25 may activate eosinophils during allergic inflammation. PMID: 24247484
31. crystal structures of homodimeric IL-17A and its complex with IL-17RA, are reported. PMID: 23695682
32. Il-17R SNPs were not associated with psoriatic arthritis susceptibility in northern Italians. PMID: 22955875
33. polymorphism of IL-17R plays no significant role in incidence of chronic periodontitis and Periimplantitis. PMID: 23852838
34. Our results might be helpful for explaining the missing heritability of the psoriasis due to epistasis and provide a deep insight into the important role of the IL23/Th17 pathway in the pathogenesis of psoriasis. PMID: 22909235
35. Data suggest that the interleukin 17 receptor A (IL17RA) minor alleles of the three single nucleotide polymorphisms (SNP) may decrease the risk of Aspirin Exacerbated Respiratory Disease (AERD) via attenuation of IL17RA gene expression. PMID: 23220496
36. IL-17A/IL-17RA interaction promoted the metastasis of OS in nude mice. PMID: 23192273
37. Our data indicates that serum IL-17 levels are significantly increased in intractable Graves disease and affected thyrocytes show functional IL-17R expression. PMID: 23501056
38. Two polymorphisms within the IL17E and IL17RA genes are associated with ESRD independent of age and sex. PMID: 23147652
39. Data show that IL-17RA, IL-17RC, IL-22R1, ERK1/2 MAPK and NF-kappaB pathways are involved in Th17 cytokine-induced proliferation. PMID: 22898922
40. protein levels of IL-17 and IL-17R positively correlated with the frequency of seizures in focal cortical dysplasias patients patients. PMID: 23334598
41. IFN-alpha could be associated with the expansion of IL-7Ralpha(low) CD45RA(+) EM CD8(+) T cells in the CMV-uninfected elderly PMID: 22484243
42. Blockage of IL-17RA with an anti-IL-17RA antibody inhibited the production of IL-6, IL-8, and MMP-3; demonstrate the functional significance of IL-17RA in psoriatic arthritis PMID: 21894442
43. mRNA levels of IL-17, IL-17R and MMP-9 were also higher in the invasive group than in the non-invasive group in human pituitary adenomas. PMID: 21279695
44. IL-17/IL-17RA signaling plays an important role in myocardial collagen metabolism in hypertension-induced diastolic dysfunction. PMID: 21530504
45. IL-17 may have an important role in the occurrence of nasal polyps by specific combination with IL-17R and over-expression in nasal polyps. PMID: 16874957
46. Human periodontal ligament fibroblasts are a target of Th17, and that IL-17 appears to up-regulate the expression of IL-23 p19 via a homeostatic mechanism involving Akt-, p38 MAPK-, and ERK 1/2-dependent NF-kappaB signalling versus the JNK/AP-1 pathway. PMID: 21145111
47. an extended SEFIR domain is required for il-17RA-mediated signal transduction. PMID: 20729198
48. Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis PMID: 11966773
49. cell membrane IL-17R is required for signaling by both IL-17A and IL-17F PMID: 15972674
50. In this JEG-3 cell model of human trophoblast, the IL-17 receptor may have a regulatory role in trophoblast invasion. PMID: 16533341

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HGNC: 5985

OMIM: 605461

KEGG: hsa:23765

STRING: 9606.ENSP00000320936

UniGene: Hs.48353