Interleukin-17 receptor A (IL17RA), also known as CD217 or IL-17R, is a transmembrane protein that serves as a critical component of the IL-17 receptor complex. It binds interleukin-17A (IL-17A) and related cytokines (IL-17F, IL-17A/F heterodimer), initiating proinflammatory signaling through heterodimerization with IL17RC. This interaction activates downstream pathways, including NF-κB, MAPK, and C/EBP, driving the expression of chemokines (CXCL1, CXCL8) and antimicrobial peptides. IL17RA is essential for host defense against extracellular pathogens but is also implicated in pathological inflammation.
Dysregulated IL17RA signaling is linked to autoimmune disorders such as psoriasis, rheumatoid arthritis, and ankylosing spondylitis. Therapeutic strategies targeting this axis include monoclonal antibodies like brodalumab, a direct IL17RA antagonist approved for moderate-to-severe plaque psoriasis. Small-molecule inhibitors disrupting IL17RA-cytokine interactions are under preclinical investigation, aiming to mitigate systemic side effects associated with biologics. Recent studies also explore its role in cancer-associated inflammation and inflammatory bowel disease, expanding potential therapeutic applications.
Recombinant Human Interleukin-17 receptor A (IL17RA), partial (Active) (CSB-AP004351HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL17RA Antibody (CSB-PA12929A0Rb)
Validated Data
Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, HL60 whole cell lysate
All lanes: IL17RA antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 97, 93 kDa
Observed band size: 93 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA12929A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following IL17RA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL17RA Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA058027 | IL17RA Antibody | Human | ELISA,WB |
CSB-PA008440 | IL17RA Antibody | Human,Mouse | WB, ELISA |
CSB-PA032717 | IL17RA Antibody | Human | ELISA,IHC |
CSB-PA703502 | IL17RA Antibody | Human | ELISA,WB,IHC |
CSB-PA12929A0Rb | IL17RA Antibody | Human, Mouse | ELISA, WB, IF |
CSB-PA12929B0Rb | IL17RA Antibody, HRP conjugated | Human | ELISA |
CSB-PA12929C0Rb | IL17RA Antibody, FITC conjugated | Human | |
CSB-PA12929D0Rb | IL17RA Antibody, Biotin conjugated | Human | ELISA |
IL17RA Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP736761MO CSB-EP736761MO CSB-BP736761MO CSB-MP736761MO CSB-EP736761MO-B |
Recombinant Mouse Interleukin-17 receptor A (Il17ra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL17RA Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP846617HU CSB-EP846617HU CSB-BP846617HU CSB-MP846617HU CSB-EP846617HU-B |
Recombinant Human Interleukin-17 receptor A (IL17RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP004351HU | Recombinant Human Interleukin-17 receptor A (IL17RA), partial (Active) | Mammalian cell |
IL17RA ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL011602HU | Human Interleukin-17 receptor A(IL17RA) ELISA kit | serum, plasma, tissue homogenate | 9.75 pg/mL |