Recombinant Human Interleukin-17 receptor A(IL17RA),partial

In Stock
Code CSB-AP004351HU
Product Type Interleukin
Size US$65
Uniprot No. Q96F46
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Alias Interleukin-17 receptor A;IL-17 receptor A;IL-17RA;CDw217;CD_antigen;CD217;IL17RA;IL17R
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to inhibit IL-17-induced IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells is less than 200 ng/ml.
Purity Greater than 90% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLW
Research Area Immunology
Source Mammalian cell
Gene Names IL17RA
Expression Region 33-320aa
Tag Info C-terminal FC-tagged
Mol. Weight 60.6 kDa
Protein Description Extracellular Domain
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Function Receptor for IL17A
Involvement in disease Immunodeficiency 51 (IMD51)
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted
Tissue Specificity Widely expressed.
Database Links

HGNC: 5985

OMIM: 605461

KEGG: hsa:23765

STRING: 9606.ENSP00000320936

UniGene: Hs.48353

Pathway IL-17 signaling pathway

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