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MYL9 (US10513561B2 Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA015318MB1HU
Size US$9799
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Product Details

Uniprot No.
P24844
Target Names
MYL9
Alternative Names
Myosin regulatory light polypeptide 9；20 kDa myosin light chain；LC20；MLC-2C；Myosin RLC；Myosin regulatory light chain 2, smooth muscle isoform；Myosin regulatory light chain 9；Myosin regulatory light chain MRLC1, MYL9, MLC2 MRLC1 MYRL2
Species Reactivity
Human
Immunogen
Recombinant Human MYL9 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
In stock
Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to the reference antibody described in US10513561B2, specifically targeting MYL9 (Myosin Light Chain 9). MYL9 is a regulatory light chain of non-muscle myosin II that plays a critical role in cytoskeletal organization, cell motility, and contractility through calcium-dependent and phosphorylation-mediated mechanisms. This protein is essential for various cellular processes including cell adhesion, migration, and cytokinesis. Dysregulation of MYL9 has been implicated in cardiovascular diseases, hypertension, cancer metastasis, and inflammatory conditions, making it an important target for understanding disease mechanisms and cellular dynamics.

The reference antibody patent US10513561B2 provides the framework for this biosimilar development, ensuring consistent binding specificity and performance characteristics. This antibody serves as a valuable research tool for investigating MYL9 expression patterns, localization studies, and its functional roles in smooth muscle contraction and non-muscle cell motility. It enables researchers to explore MYL9-mediated signaling pathways and its involvement in pathological conditions across multiple research disciplines.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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MYL9 Proteins

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Target Background

Function
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation.
Gene References into Functions
  1. MYL9 expression might be a promising prognostic marker and therapeutic target in ESCC PMID: 28388691
  2. At the cleavage furrow Arv1 recruits myosin heavy chain 9 (MYH9) and myosin light chain 9 (MYL9) by interacting with IQ-motif-containing GTPase-activating protein (IQGAP1). PMID: 27104745
  3. These findings suggested that low MYLK and MYL9 expressions might be associated with the development of NSCLC. PMID: 25179839
  4. the decreased expression of MYL9 may play an important role in tumor progression of prostate cancer PMID: 24338276
  5. Overexpression of MRTF-A significantly promoted the migration of MCF-7 cells through its transactivation effects on MYL9 and CYR61 genes PMID: 24084383
  6. Overexpression of SMYD3 promotes MRTF-A-mediated upregulation of MYL9 and migration of MCF-7 breast cancer cells PMID: 24189459
  7. surface CD3 expression proceeds through both MYL9-dependent and MYL9-independent pathways (i.e. the protein kinase C- dependent pathway) in Jurkat cells. PMID: 23538510
  8. The FHC-mediated structural perturbations in RLC that affect Ca(2+) binding properties of mutated myocardium are responsible for triggering the abnormal function of the heart that in turn might initiate a hypertrophic process and lead to heart failure. PMID: 16076902
  9. Smooth muscle type isoform, MLC-2C, is the inducible isoform, and might play a crucial role in monocyte/macrophage cell lineage. PMID: 18480596
  10. use of a shRNA to decrease MYL9 expression showed that MYL9 was involved in proplatelet formation PMID: 19724058

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Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Tissue Specificity
Smooth muscle tissues and in some, but not all, nonmuscle cells.
Database Links

HGNC: 15754

OMIM: 609905

KEGG: hsa:10398

STRING: 9606.ENSP00000279022

UniGene: Hs.504687

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