Name: PEAR1 (SV001 Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA017765MB1HU

Product Details

Uniprot No.

Q5VY43

Target Names

PEAR1

Alternative Names

PEAR1 research-grade biosimilar; SV001 research-grade biosimilar; SV 001 research-grade biosimilar; SV-001 research-grade biosimilar ;PEAR1 antibody; MEGF12 antibody; Platelet endothelial aggregation receptor 1 antibody; hPEAR1 antibody; Multiple epidermal growth factor-like domains protein 12 antibody; Multiple EGF-like domains protein 12 antibody

Species Reactivity

Human

Immunogen

Recombinant Human PEAR1 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to reference antibody SV001, targeting PEAR1 (Platelet Endothelial Aggregation Receptor 1). PEAR1 is a transmembrane protein predominantly expressed on platelets and endothelial cells that plays a critical role in platelet contact-induced activation and aggregation. Upon platelet activation, PEAR1 undergoes phosphorylation and modulates integrin αIIbβ3 signaling, thereby influencing hemostasis and thrombosis. Genetic variants in PEAR1 have been associated with altered platelet reactivity and cardiovascular disease risk, making it an important target for investigating interindividual variability in antiplatelet therapy response and thrombotic disorders.

This biosimilar antibody provides researchers with a reliable tool for investigating PEAR1 expression, localization, and function in platelet biology and vascular research. It supports studies examining platelet activation mechanisms, endothelial-platelet interactions, and the molecular basis of cardiovascular pathophysiology. The antibody is suitable for research exploring personalized medicine approaches in antiplatelet treatment and understanding genetic contributions to thrombotic risk.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.

Gene References into Functions

PEAR1 rs56260937 minor allele was an independent predictor of revascularization events. PMID: 29212986
For Chinese patients with ACS treated with aspirin and clopidogrel, genetic mutations in rs822441/rs822442 in PEAR1 correlated significantly with platelet activity after adjusting for CYP2C19 *2/*3 alleles. PMID: 29407631
PEAR1 methylation corresponded to variability in expression of ISGL20L2, RRNAD1, MRLP24, HDGF and PRCC. PMID: 29614055
PEAR1 rs12041331 polymorphism may influence ticagrelor pharmacodynamics PMID: 27937053
DNA methylation at 4 different loci of PEAR1 during in vitro megakaryopoiesis, was studied. PMID: 27313330
In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that PEAR1 might be a susceptibility gene for cardiovascular complications PMID: 28449647
PEAR1 genetic variations were strongly associated with platelet reactivity in a Chinese patient population with coronary heart disease undergoing dual antiplatelet therapy with aspirin and clopidogrel. PMID: 26962983
A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. PMID: 27641736
in a Chinese pedigree, SNP rs778026543, but not rs1952294 and rs822442, may be a susceptibility for pulmonary thromboembolism PMID: 28002340
Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis. PMID: 26156496
Results suggest that genetic variation of PEAR1 is a significant determinant of endothelial function through pathways implicated in cardiovascular disease. PMID: 26406321
FcepsilonRI alpha-chain is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand. PMID: 25713122
genetic variability of GAS6 and PEAR1 genes may be associated with platelet hyperaggregability PMID: 25703520
A common genetic variant in PEAR1 (rs12041331) reproducibly influenced platelet aggregation in aspirin-treated patients with coronary artery disease. PMID: 25360888
study suggests that PEAR1 is not a hypertension susceptibility gene in humans. PMID: 25541647
The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics PMID: 23859572
additional exonic variants in PEAR1 that may also determine variability in platelet aggregation, were identified. PMID: 23704978
A-allele carriers of rs12041331 in the platelet endothelial aggregation receptor-1 (PEAR1) gene were more likely to experience a cardiovascular event or death compared with GG homozygotes PMID: 23392654
PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. PMID: 23667054
A specific intronic PEAR1 gene variant is ientified that associated with greater platelet aggregability and protein expression. PMID: 21791418
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20526338
PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts PMID: 15851471
C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets PMID: 18511696
Observational study of gene-disease association. (HuGE Navigator) PMID: 19429868
Observational study of gene-disease association. (HuGE Navigator) PMID: 18511696

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Subcellular Location

Cell membrane; Single-pass membrane protein.

Protein Families

MEGF family

Tissue Specificity

Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord

Database Links

HGNC: 33631

OMIM: 610278

KEGG: hsa:375033

STRING: 9606.ENSP00000292357

UniGene: Hs.142003

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Code	CSB-RA017765MB1HU
Size	US$9799
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PEAR1 (SV001 Biosimilar) Recombinant Monoclonal Antibody

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Target Background