PEAR1 Antibody, HRP conjugated

1. PEAR1 rs56260937 minor allele was an independent predictor of revascularization events. PMID: 29212986
2. For Chinese patients with ACS treated with aspirin and clopidogrel, genetic mutations in rs822441/rs822442 in PEAR1 correlated significantly with platelet activity after adjusting for CYP2C19 *2/*3 alleles. PMID: 29407631
3. PEAR1 methylation corresponded to variability in expression of ISGL20L2, RRNAD1, MRLP24, HDGF and PRCC. PMID: 29614055
4. PEAR1 rs12041331 polymorphism may influence ticagrelor pharmacodynamics PMID: 27937053
5. DNA methylation at 4 different loci of PEAR1 during in vitro megakaryopoiesis, was studied. PMID: 27313330
6. In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that PEAR1 might be a susceptibility gene for cardiovascular complications PMID: 28449647
7. PEAR1 genetic variations were strongly associated with platelet reactivity in a Chinese patient population with coronary heart disease undergoing dual antiplatelet therapy with aspirin and clopidogrel. PMID: 26962983
8. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. PMID: 27641736
9. in a Chinese pedigree, SNP rs778026543, but not rs1952294 and rs822442, may be a susceptibility for pulmonary thromboembolism PMID: 28002340
10. Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis. PMID: 26156496
11. Results suggest that genetic variation of PEAR1 is a significant determinant of endothelial function through pathways implicated in cardiovascular disease. PMID: 26406321
12. FcepsilonRI alpha-chain is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand. PMID: 25713122
13. genetic variability of GAS6 and PEAR1 genes may be associated with platelet hyperaggregability PMID: 25703520
14. A common genetic variant in PEAR1 (rs12041331) reproducibly influenced platelet aggregation in aspirin-treated patients with coronary artery disease. PMID: 25360888
15. study suggests that PEAR1 is not a hypertension susceptibility gene in humans. PMID: 25541647
16. The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics PMID: 23859572
17. additional exonic variants in PEAR1 that may also determine variability in platelet aggregation, were identified. PMID: 23704978
18. A-allele carriers of rs12041331 in the platelet endothelial aggregation receptor-1 (PEAR1) gene were more likely to experience a cardiovascular event or death compared with GG homozygotes PMID: 23392654
19. PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. PMID: 23667054
20. A specific intronic PEAR1 gene variant is ientified that associated with greater platelet aggregability and protein expression. PMID: 21791418
21. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20526338
22. PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts PMID: 15851471
23. C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets PMID: 18511696
24. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429868
25. Observational study of gene-disease association. (HuGE Navigator) PMID: 18511696

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HGNC: 33631

OMIM: 610278

KEGG: hsa:375033

STRING: 9606.ENSP00000292357

UniGene: Hs.142003