Name: SIGLEC6 (AK-006 Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA021300MB1HU

Product Details

Uniprot No.

O43699

Target Names

SIGLEC6

Alternative Names

AK006 research-grade biosimilar; AK 006 research-grade biosimilar ;SIGLEC6 antibody; CD33L antibody; CD33L1 antibody; OBBP1 antibody; Sialic acid-binding Ig-like lectin 6 antibody; Siglec-6 antibody; CD33 antigen-like 1 antibody; CDw327 antibody; Obesity-binding protein 1 antibody; OB-BP1 antibody; CD antigen CD327 antibody

Species Reactivity

Human

Immunogen

Recombinant Human SIGLEC6 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems. Guaranteed Quality ① Antibody purity > 95% tested by SDS-PAGE. ② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is a research-grade biosimilar to AK-006, designed to specifically target SIGLEC6 (Sialic Acid-Binding Ig-Like Lectin 6), a member of the CD33-related siglec family of inhibitory receptors. SIGLEC6 is predominantly expressed on mast cells, basophils, and placental trophoblasts, where it functions as an immunoregulatory receptor that modulates cellular activation through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs). This receptor plays a critical role in regulating mast cell degranulation and inflammatory responses, making it particularly relevant in allergic diseases, chronic urticaria, and other mast cell-mediated disorders.

The reference antibody AK-006 (lirentelimab) has been extensively studied as a therapeutic candidate for mast cell-driven diseases, including chronic spontaneous urticaria, eosinophilic gastritis, and indolent systemic mastocytosis. This biosimilar antibody serves as a valuable research tool for investigating SIGLEC6 biology, mast cell function, and the immunomodulatory mechanisms underlying allergic and inflammatory conditions. It enables researchers to explore mast cell depletion strategies and validate SIGLEC6 as a therapeutic target in preclinical studies.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene References into Functions

Siglec6 and leptin play a role in the aberrant properties characteristic of gestational trophoblastic disease, namely excess proliferation and invasion. PMID: 23089140
Siglec-6 expression is increased in preterm preeclampsia placentas. PMID: 23171684
GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway. PMID: 21880722
the negative signaling potential of Siglec-6 may have a role in human-specific placental expression, to slow the tempo of the human birth process PMID: 17580316
Preeclampsia involves changes in the gene expression of SIGLEC6 in placental cytotrophoblasts. PMID: 18818296

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family

Tissue Specificity

Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.

Database Links

HGNC: 10875

OMIM: 604405

KEGG: hsa:946

STRING: 9606.ENSP00000401502

UniGene: Hs.720304

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SIGLEC6 (AK-006 Biosimilar) Recombinant Monoclonal Antibody

Product Details

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Target Background