SIGLEC6 Antibody

Code CSB-PA021300LA01HU
Size US$166
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  • Western blot
    All lanes: SIGLEC6 antibody at 6µg/ml
    Lane 1: Human high value serum
    Lane 2: A549 whole cell lysate
    Lane 3: Caco-2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 50, 39, 49, 38, 43, 45 kDa
    Observed band size: 50 kDa

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA021300LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SIGLEC6 Polyclonal antibody
Uniprot No.
Target Names
SIGLEC6
Alternative Names
SIGLEC6; CD33L; CD33L1; OBBP1; Sialic acid-binding Ig-like lectin 6; Siglec-6; CD33 antigen-like 1; CDw327; Obesity-binding protein 1; OB-BP1; CD antigen CD327
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sialic acid-binding Ig-like lectin 6 protein (76-269AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SIGLEC6 Antibody (Product code: CSB-PA021300LA01HU) is Non-conjugated. For SIGLEC6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA021300LB01HU SIGLEC6 Antibody, HRP conjugated ELISA
FITC CSB-PA021300LC01HU SIGLEC6 Antibody, FITC conjugated
Biotin CSB-PA021300LD01HU SIGLEC6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Gene References into Functions
  1. Siglec6 and leptin play a role in the aberrant properties characteristic of gestational trophoblastic disease, namely excess proliferation and invasion. PMID: 23089140
  2. Siglec-6 expression is increased in preterm preeclampsia placentas. PMID: 23171684
  3. GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway. PMID: 21880722
  4. the negative signaling potential of Siglec-6 may have a role in human-specific placental expression, to slow the tempo of the human birth process PMID: 17580316
  5. Preeclampsia involves changes in the gene expression of SIGLEC6 in placental cytotrophoblasts. PMID: 18818296

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Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Protein Families
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Tissue Specificity
Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
Database Links

HGNC: 10875

OMIM: 604405

KEGG: hsa:946

STRING: 9606.ENSP00000401502

UniGene: Hs.720304

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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