ACOT7 Antibody

Code CSB-PA001169ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001169ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ACOT7 Polyclonal antibody
Uniprot No.
Target Names
ACOT7
Alternative Names
ACH1 antibody; ACOT 7 antibody; ACOT7 antibody; ACT antibody; Acyl CoA thioesterase 7 antibody; Acyl CoA thioesterase long chain antibody; Acyl-CoA thioesterase 7 antibody; BACH antibody; BACH_HUMAN antibody; Brain acyl CoA hydrolase antibody; Brain acyl-CoA hydrolase antibody; CTE-II antibody; CTE-IIa antibody; Cytosolic acyl coenzyme A thioester hydrolase antibody; hBACH antibody; LACH antibody; LACH1 antibody; Long chain acyl-CoA thioester hydrolase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cytosolic acyl coenzyme A thioester hydrolase protein (151-380AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain.
Gene References into Functions
  1. PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells. PMID: 28518146
  2. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA. PMID: 28472401
  3. the human BACH gene can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs PMID: 12435388
  4. BACH was deranged in hippocampus of mesial temporal lobe epilepsy patients. PMID: 15592755
Subcellular Location
[Isoform 4]: Cytoplasm, cytosol.; [Isoform 6]: Cytoplasm, cytosol.; [Isoform 1]: Mitochondrion.; [Isoform 5]: Mitochondrion.
Tissue Specificity
Isoform 4 is expressed exclusively in brain.
Database Links

HGNC: 24157

OMIM: 602587

KEGG: hsa:11332

STRING: 9606.ENSP00000367086

UniGene: Hs.126137

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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