ACR Antibody

Datasheet

Code	CSB-PA260955
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA260955(ACR Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: A549 cells, Primary antibody: CSB-PA260955(ACR Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P10323

Target Names

ACR

Alternative Names

Acr antibody; ACRO_HUMAN antibody; Acrosin heavy chain antibody; Acrosin precursor antibody; ACRS antibody; Preproacrosin antibody; Proacrosin antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human ACR

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:15-1:50

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Gene References into Functions

Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR - 71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively. PMID: 23675907
Sperm DNA damage is closely related with sperm-nucleoprotein transition, acrosin activity and seminal parameters. PMID: 23297503
DNA immunization against proacrosin impairs fertility in male mice. PMID: 22452365
Binding sites for recombinant human zona pellucida (ZP) glycoproteins located at the N- and C-termini of proacrosin reveal a key role of the proenzyme in the interaction. PMID: 15950651

Protein Families

Peptidase S1 family

Database Links

HGNC: 126

OMIM: 102480

KEGG: hsa:49

STRING: 9606.ENSP00000216139

UniGene: Hs.370870

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