COQ8B Antibody

Code CSB-PA839305LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, HepG2 whole cell lysate
    All lanes: COQ8B antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 61, 56 kDa
    Observed band size: 61, 56 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA839305LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA839305LA01HU at dilution of 1:100

  • Immunofluorescent analysis of A549 cells using CSB-PA839305LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) COQ8B Polyclonal antibody
Uniprot No.
Target Names
COQ8B
Alternative Names
COQ8B; ADCK4; Atypical kinase COQ8B, mitochondrial; AarF domain-containing protein kinase 4; Coenzyme Q protein 8B
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Atypical kinase COQ8B, mitochondrial protein (10-137AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The COQ8B Antibody (Product code: CSB-PA839305LA01HU) is Non-conjugated. For COQ8B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA839305LB01HU COQ8B Antibody, HRP conjugated ELISA
FITC CSB-PA839305LC01HU COQ8B Antibody, FITC conjugated
Biotin CSB-PA839305LD01HU COQ8B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration.
Gene References into Functions
  1. Mutations in ADCK4 resulted in reduced CoQ10 levels and reduced mitochondrial respiratory enzyme activity in cells isolated from individuals with steroid-resistant nephrotic syndrome & transformed lymphoblasts. PMID: 24270420
Involvement in disease
Nephrotic syndrome 9 (NPHS9)
Subcellular Location
Mitochondrion membrane; Single-pass membrane protein. Cytoplasm, cytosol. Cell membrane.
Protein Families
Protein kinase superfamily, ADCK protein kinase family
Tissue Specificity
Widely expressed, including renal podocytes.
Database Links

HGNC: 19041

OMIM: 615567

KEGG: hsa:79934

STRING: 9606.ENSP00000315118

UniGene: Hs.130712

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