AGGF1 Antibody

1. Aggf1 has a role in regulating vascular injury. PMID: 28153879
2. High expression of AGGF1 predicts poor prognosis in gastric cancer patients. PMID: 28289272
3. AGGF1 gene polymorphism does not affect the risk of varicose veins of the legs in ethnic Russians. PMID: 27704351
4. Overexpression of AGGF1 is correlated with angiogenesis in hepatocellular carcinoma. PMID: 25796501
5. AGGF1 reduces myocardial apoptosis and inflammation and enhances angiogenesis, leading to decreased infarct size after I/R injury. PMID: 24893993
6. results of this study indicate that hypoxia down-regulates expression of the AGGF1 protein, but not AGGF1 mRNA, by inducing expression of miR-27a PMID: 24462738
7. AGGF1 potently attenuated TNF-alpha triggered NF-kappaB pathway, as indicated by the decreased promoter activity, nuclear distribution and phosphorylation of NF-kappaB p65 subunit as well as the increased protein level of IkappaBalpha. PMID: 23628701
8. analysis of sphingolipid modulation of angiogenic factor expression in neuroblastoma PMID: 21576349
9. results define VG5Q as an angiogenic factor, establish VG5Q as a susceptibility gene for Klippel-Trenaunay syndrome, and show that increased angiogenesis is a molecular pathogenic mechanism of KTS PMID: 14961121
10. VG5Q, E133K is a mutation that causes Klippel-Trenaunay and other overgrowth syndromes. PMID: 16443853
11. This review describes the somatic mutation for angiogenic factor VG5Q, which may be the cause of the multisystem disorder Klippel-Trenaunay syndrome. PMID: 16911369
12. identified two tagSNPs, rs13155212 and rs7704267 that capture information for all common variants in AGGF1 as a candidate susceptibility gene for Klippel-Trenaunay syndrome PMID: 18564129
13. Knockdown of GATA1 expression by siRNA reduced expression of AGGF1, and resulted in endothelial cell apoptosis and inhibition of vessel formation. PMID: 19556247

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HGNC: 24684

OMIM: 149000

KEGG: hsa:55109

STRING: 9606.ENSP00000316109

UniGene: Hs.634849