AKAP10 Antibody

Datasheet

Code	CSB-PA001519ESR1HU
Size	US$166
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Image	Western blot All lanes: AKAP10 antibody at 7μg/ml Lane 1: 293T whole cell lysate Lane 2: Hela whole cell lysate Lane 3: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 74 kDa Observed band size: 74 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA001519ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA001519ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AKAP10 Polyclonal antibody

Uniprot No.

O43572

Target Names

AKAP10

Alternative Names

AKAP10A-kinase anchor protein 10 antibody; mitochondrial antibody; AKAP-10 antibody; Dual specificity A kinase-anchoring protein 2 antibody; D-AKAP-2 antibody; Protein kinase A-anchoring protein 10 antibody; PRKA10 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human A-kinase anchor protein 10, mitochondrial protein (413-662AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.

Gene References into Functions

Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane. PMID: 28553927
Significant association between the AKAP10 polymorphisms and reduced risk of Preterm birth in the Malays was observed. PMID: 26110499
Its signaling pathway is associated with the progression and prognosis of colorectal neoplasms. PMID: 25213315
Described is a structure of D-AKAP2 in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1. PMID: 25348485
Studied the clinicopathologic significance of A-kinase anchoring proteins 10 (AKAP 10) expression and the relationship with its polymorphism in colorectal cancer. PMID: 23468363
Questioned whether 1936A>G is associated with metabolic changes in newborns that are predictive of the metabolic phenotype in adults. Demonstrate an association between 1936G variant and total cholesterol level in cord blood of Polish newborns. PMID: 23095189
There is possible association between a 1936G AKAP10 variant and blood pressure in Polish newborns. PMID: 22817328
No significant differences were found in AKAP10 genotype or allele distribution between the age groups (newborn vs. nonagenerian) for either gender. PMID: 23092224
Results suggest G1936 polymorphism in A-kinase-anchoring protein is preventative factor against preterm birth, in contrast with previously asserted negative effects in adults. PMID: 21701445
Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2. PMID: 20159461
AKAP10 single nucleotide polymorphism is associated with increased risk of arrhythmia during kidney transplantation. PMID: 19857670
There was a significant association between AKAP10 gene 2073A/G polymorphism and colorectal cancer. PMID: 19462906
deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein PMID: 12206784
A variant of the kinase-binding domain of this enzyme involves a disease susceptibility polymorphism. PMID: 12646697
Results describe the structural features of dual-specificity A kinase-anchoring protein 2 (D-AKAP2) and its interaction with protein kinase A (PKA). PMID: 15488188
These studies suggest a role for AKAP10 in heart rhythm control. PMID: 17485678
AKAP10 2073A>G variation is associated with an increased risk of colorectal cancer in the Chinese population. PMID: 19209010
the AKAP10 Val allele predicted greater resting heart rate and heart rate variability PMID: 19496216
D-AKAP2 promotes accumulation of recycling proteins in the Rab4/Rab11-positive endocytic recycling compartment PMID: 19797056

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Involvement in disease

Sudden cardiac death (SCD)

Subcellular Location

Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.

Database Links

HGNC: 368

OMIM: 115080

KEGG: hsa:11216

STRING: 9606.ENSP00000225737

UniGene: Hs.642676

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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