AKR1A1 Antibody

Datasheet

Code	CSB-PA967994
Size	US$297
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Image	Western blot analysis of extracts from COLO205 cells and NIH-3T3 cells, using AKR1A1 antibody.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AKR1A1 Polyclonal antibody

Uniprot No.

P14550

Target Names

AKR1A1

Alternative Names

AK1A1_HUMAN antibody; Akr1a1 antibody; Alcohol dehydrogenase [NADP+] antibody; Alcohol dehydrogenase antibody; Aldehyde reductase antibody; Aldo keto reductase family 1 member A1 (aldehyde reductase) antibody; Aldo-keto reductase family 1 member A1 antibody; ALDR1 antibody; ALR antibody; ARM antibody; DD3 antibody; MGC12529 antibody; MGC1380 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from C-terminal of Human AKR1A1.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Displays no reductase activity towards retinoids.

Gene References into Functions

Data (including data from studies in knockout and transgenic mice) suggest that AKR1A1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity. PMID: 29763686
prostaglandin F synthase activity of human and bovine aldo-keto reductases PMID: 23747692
AKR1A1 could be involved in the metabolism of 4-hydroxynonenal and play a role in the resistance to oxidative stress PMID: 23643085
AKR1A1 has little effect on the production of gamma-hydroxybutyrate PMID: 21276435
structure of Apo R268A human aldose reductase reveals hinges and latches that control the kinetic mechanism PMID: 15769597
the binding site residues deviating between ALR1 and ALR2 influence ligand affinity in a complex interplay, presumably involving changes of dynamic properties and differences of the solvation/desolvation balance upon ligand binding PMID: 18495158

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Subcellular Location

Cytoplasm, cytosol. Apical cell membrane.

Protein Families

Aldo/keto reductase family

Tissue Specificity

Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.

Database Links

HGNC: 380

OMIM: 103830

KEGG: hsa:10327

STRING: 9606.ENSP00000312606

UniGene: Hs.474584

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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