AKR1C1 Antibody

1. AKR1C1 activates STAT3 pathway to promote NSCLC metastasis. PMID: 29344298
2. Decreased invasion caused by AKR1C1 knockdown suggests a novel role of AKR1C1 in cancer invasion, which is probably due to the regulation of Rac1, Src, or Akt. An inflammatory cytokine, interleukin-1beta, was found to increase AKR1C1 in bladder cancer cell lines. PMID: 27698389
3. Data show that increased levels of AKR1C1/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB). PMID: 26934124
4. the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells. PMID: 28259989
5. Activation of AKR1C1/ERbeta induces apoptosis by downregulation of c-FLIP in prostate cancer cells. PMID: 25816367
6. results suggest a gender-specific modulatory effect of AKR1C1 on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain PMID: 24390875
7. Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency. PMID: 24189185
8. activation of the Nrf2/AKR1C axis may contribute to oxaliplatin resistance in gastric carcinoma PMID: 23933386
9. The involvement of up-regulated AKR1C1, AKR1C3 and proteasome in CDDP resistance of colon cancers. PMID: 23165153
10. Which promoted significant reduction of AKR1C1 and AKR1C2 expression. PMID: 23183084
11. Data suggest that interleukin-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of AKR1C1 and AKR1C2. PMID: 22064385
12. It was concluded that the truncated E6 protein of human papillomavirus 16, known as E6*I, has a novel function in upregulating expression of human AKR1C. PMID: 22278827
13. role of AKR1C1in the metabolism of testosterone and progesterone via the 5beta-reductase pathway. PMID: 21521174
14. enhanced metabolism of progesterone by SRD5A1 and the 20alpha-HSD and 3alpha/beta-HSD activities of AKR1C1, AKR1C2 and AKR1C3 PMID: 21232532
15. analysis of single nucleotide polymorphisms of AKR1C1 and AKR1C2 PMID: 21217827
16. Functionally expressed human AKR1C1 (20alpha-hydroxysteroid dehydrogenase) in the fission yeast Schizosaccharomyces pombe and demonstrate the ability of the resulting yeast strain to efficiently catalyze the reduction of progesterone or dydrogesterone. PMID: 20727920
17. non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors PMID: 20673851
18. Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer PMID: 11956619
19. Reduction of dihydrodiol dehydrogenase expression is associated with resected hepatocellular carcinoma PMID: 12579257
20. progesterone itself contributes to the regulation of local progesterone concentration through 20alpha-HSD levels in endometrial stromal cells at peri-implantation periods. PMID: 12733716
21. X ray diffraction and site-directed mutagenesis: identification of an alternative binding site for C21-steroids PMID: 12899831
22. Glaucomatous optic nerve head astrocytes express a higher level of 3 alpha-HSD isoform AKR1C1 and its mRNA than normal astrocytes. PMID: 13678667
23. Expression of SRD5A1 (5alphaR1) and SRD5A2 (5alphaR2) is elevated, and expression of AKR1C1 (20alpha-HSO), AKR1C2 (3alpha-HSO3) and AKR1C3 (3alpha-HSO2) is reduced in tumorous as compared to normal breast tissue. PMID: 15212687
24. Loss of AKR1C1 and AKR1C2 in breast cancer results in decreased progesterone catabolism, which, in combination with increased PR expression, may augment progesterone signaling by its nuclear receptors. PMID: 15492289
25. mRNA abundance and activity of AKR1C enzymes in abdominal adipose tissue are positive correlates of adiposity in women. Increased progesterone and/or dihydrotestosterone reduction in abdominal adipose tissue may impact fat cell metabolism. PMID: 15494612
26. The expression of AKR1C1 and AKR1C3 in endometrial cancer will govern the ratio of P:E2. PMID: 16338060
27. DDH may play important roles in tumor progression of squamous cell carcinoma via induction of apoptosis- and drug-resistance PMID: 16361083
28. Activity of AKR1C1 in overall oracin reduction was one order of magnitude higher compared to AKR1C2 and 1C4. PMID: 17618725
29. Carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 and 2 (mPGES-1, mPGES-2), cytosolic prostaglandin E synthase (cPGES), aldoketoreductase (AKR1C1) and prostaglandin F synthase (AKR1C3) were all expressed in hair follicles. PMID: 17697149
30. Carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 and 2 (mPGES-1, mPGES-2), cytosolic prostaglandin E synthase (cPGES), the aldoketoreductase AKR1C1 and the prostaglandin F synthase AKR1C3 were all expressed in hair follicles. PMID: 17697149
31. Overexpression of AKR1C1 counteracted the S-phase accumulation of cells and apoptosis caused by MTX treatment. This suggests a role of AKR1C1 in cell proliferation. PMID: 17945194
32. Incubations of normal human bronchial epithelial cells with individual heavy metals showed that the upregulation of AKR1C1 and AKR1C2 was predominantly caused by lead. PMID: 18654764
33. Induction of preadipocyte differentiation increased expression levels of AKR1C1 and modified the pattern of progesterone metabolism substantially, leaving 20alpha-hydroxyprogesterone as the main metabolite generated. PMID: 18984031
34. human AKR1C enzymes (AKR1C1-4) are able to reduce conjugated steroids such as Dht-17beta-glucuronide (DhtG), Dht-17beta-sulfate (DhtS), and Tib-17beta-sulfate (TibS) PMID: 19218247
35. AKR1C subfamily genes are stress-inducible and might function as survival factors in keratinocytes. PMID: 19320734
36. AKR1C isoforms as a novel target of jasmonates in cancer cells. PMID: 19487289
37. Human AKR1C enzymatic activity plays crucial roles on induction of neoplastic transformation of mouse NIH3T3 cells. PMID: 19696165

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HGNC: 384

OMIM: 600449

KEGG: hsa:1645

STRING: 9606.ENSP00000370254

UniGene: Hs.460260