ALDH3A1 Antibody

1. ALDH3A1 appears to play an essential role in protecting cellular proteins against aggregation under stress conditions PMID: 28526614
2. ALDH3A1 confers a multi-modality resistance phenotype in MCF-7 cells PMID: 27276244
3. Molecular docking analysis depicted that Sulforaphane fits into the active site of ALDH3A1, and facilitates the catalytic mechanism of the enzyme. PMID: 27997560
4. ALDH-3A1 expression correlates well with gastric cancer dysplasia and grades, differentiation, lymph node metastasis and cancer stage. PMID: 27279633
5. Down-regulation of ALDH3 activity in trophoblast stem cells initiates trophoblast differentiation during placental development. PMID: 26124079
6. ALDH3A1 has a role in the maintenance of corneal epithelial homeostasis by simultaneously modulating proliferation and differentiation through both enzymatic and non-enzymatic mechanisms PMID: 26751691
7. Reported increased expression of ALDH3A1, PDIA3, and PRDX2 in pterygia using a proteomic approach. These proteins are presumed to have a protective role against oxidative stress-induced apoptosis. PMID: 25221425
8. SiRNA-mediated suppression of ALDH3A1 blocked ALDH enzymatic activity and augmented cytotoxicity in CSE-exposed cells. PMID: 24316006
9. While ALDH3A1 was not found in prostate glands, it was present in prostatic intraepithelial neoplasia, further increased in carcinomas, and upregulated in lymphatic metastases. ALDH3A1 increased in DU145-cell-derived lung metastasis vs. local xenografts. PMID: 24762960
10. No correlation between ALDH3A1 expression and patient survival or tumour recurrence was observed.In conclusion, ALDH3A1 is a marker of activation of the Wnt/ss-catenin pathway in hepatocellular carcinoma PMID: 24276407
11. ALDH3A1 provides exceptional protection from the adverse effects of pathophysiological concentrations of 4-HNE such as may occur during periods of oxidative stress PMID: 22406320
12. through modulation of PPARgamma or ALDH3A1, it may be possible to reduce cell proliferation in tumor cells or stimulate cell proliferation in normal cells during tissue regeneration. PMID: 21251908
13. the UV-induced inactivation of ALDH3A1 is a result of non-native aggregation and associated structural changes rather than specific damage to the active site Cys PMID: 21203538
14. Antihypertensives, nonopioid analgesics and hormonal contraceptives significantly affect the salivary ALDH3A1 activity. PMID: 21229876
15. These findings suggest that a high level of expression of ALDH3 in cancerous liver tissues resulted from the expression or activation of at least two nuclear proteins reacting to the ALDH3 promoter region. PMID: 9855707
16. ADH3*1 allele associated with high ADH activity and acetyaldehyde-DNA adducts in lung; may be a risk factor for lung cancer PMID: 12367788
17. ALDH3A1 is a regulatory element of the cellular defense system that protects corneal epithelium against UV-induced oxidative damage PMID: 12706498
18. Enzyme activity and localization of ALDH3A1 in the cornea. PMID: 12943535
19. ALDH3A1 may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle PMID: 15905174
20. In most cases, ALDH3A1 activity in tumor and bordering tissues was higher than in a control group PMID: 18536178
21. the mechanism of salivary ALDH3A1 inactivation must be related to free radical activity, presumably in the salivary gland, but it is not simply correlated with antioxidatn capacity of saliva PMID: 19894643

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HGNC: 405

OMIM: 100660

KEGG: hsa:218

STRING: 9606.ENSP00000225740

UniGene: Hs.531682