AMICA1 Antibody

Code CSB-PA001668GA01HU
Size $600
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
JAML
Alternative Names
adhesion molecule AMICA antibody; Adhesion molecule interacting with CXADR antigen 1 antibody; adhesion molecule interacts with CXADR antigen 1 antibody; adhesion molecule that interacts with CXADR antigen 1 antibody; AMICA antibody; Amica1 antibody; CREA7-1 antibody; CREA7-4 antibody; Dendritic cell-specific protein CREA7-1 antibody; dendritic-cell specific protein CREA7-1 antibody; dendritic-cell specific protein CREA7-4 antibody; FLJ37080 antibody; Gm638 antibody; JAML1_HUMAN antibody; junctional adhesion molecule antibody; Junctional adhesion molecule-like antibody; Junctional adhesion molecule-like precursor antibody; MGC118814 antibody; MGC118815 antibody; UNQ722/PRO1387 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human AMICA1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Gene References into Functions
  1. expressed on leukocytes with a possible role in leukocyte transmigration PMID: 12869515
  2. Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state. PMID: 19064666
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
Protein Families
Immunoglobulin superfamily
Tissue Specificity
Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).
Database Links

HGNC: 19084

OMIM: 609770

KEGG: hsa:120425

STRING: 9606.ENSP00000348635

UniGene: Hs.16291

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*