ANKRD1 Antibody

1. review of CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases [review] PMID: 27143260
2. These data suggest that hepatitis C virus coopts ANKRD1 for its own propagation and up-regulation of ANKRD1 may contribute to hepatitis C virus-mediated liver pathogenesis. PMID: 26860204
3. To the Ankrd1, it is not responsive to the cardiotoxic drug Doxorubicin, suggesting that different mechanisms govern their expression in cardiac cells. PMID: 25585647
4. The association of ANKRD1 with antiapoptotic response suggests its role as myocyte survival factor during late stage heart disease, warranting further studies on ANKRD1 during end-stage heart failure. PMID: 25961010
5. Report structure activity relationships for ANKRD1. PMID: 25125175
6. ANKRD1 has a significant role in the regulation of apoptosis in human ovarian cancer cells PMID: 24531715
7. Augmented CARP expression may be a common molecular event in failing hearts regardless of cardiomyopathic aetiology. PMID: 19359327
8. Report impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue. PMID: 23572067
9. the 26S proteasome is the dominant regulator of Ankrd1/CARP degradation, and that Ankrd1/CARP half-life is significantly longer in cardiomyocytes (h) than endothelial cells (min). PMID: 22892129
10. Ankrd1 and desmin may play important roles in airway smooth muscle cell homeostasis. PMID: 22085644
11. CARP and its regulator calpain 3 appear to occupy a central position in the important cell fate-governing NF-kappaB pathway in skeletal muscle PMID: 20860623
12. p53 operates as an upstream effector of Ankrd1/CARP, by up regulating the proximal ANKRD1 promoter PMID: 20599664
13. On the basis of genetic and functional analysis of CARP mutations, ANKRD1 has been identified as a new gene associated with dilated cardiomyopathy, accounting for approximately 2% of the 231 cases studied. PMID: 19525294
14. CD45 lateral mobility is regulated by the spectrin-ankyrin cytoskeleton of T cells PMID: 20164196
15. Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure. PMID: 12054667
16. CARP expression is observed by in situ hybridization in endothelial cells lining human atherosclerotic plaques, whereas lesion macrophages are devoid of CARP; it is induced by activin A in cultured intimal smooth muscle cells. PMID: 12524226
17. endogenous ANKRD1 and calsequestrin are co-enriched in piglet cardiac Purkinje cells PMID: 15698842
18. CARP interacts with itself and desmin. CARP, ankrd2, and DARP contain potential coiled-coil dimerization motifs within their unique aminoterminal domains that mediate the formation of homo-dimers. PMID: 16450059
19. CARP was expressed in renal podocytes at a high level in 10 of 13 cases of crescentic glomerulonephritis, 7 of 19 cases of diabetic nephropathy, and 12 of 20 cases of lupus nephritis. PMID: 17239933
20. cloned both translocation breakpoints and mapped the ANKRD1 gene, encoding a cardiac transcriptional regulator, 130 kb proximally to the breakpoint on chromosome 10, in total anomalous pulmonary venous return, a congenital heart defect PMID: 18273862
21. Our results indicate that CARP is a sensitive and specific marker for rhabdomyosarcoma and that it will be useful for the differential diagnosis of rhabdomyosarcoma. PMID: 18656235
22. We suggest that CDH1 cytoplasmic immunolocalization as a result of increased IGF-II levels identifies those nonmuscle invasive presentations most likely to recur PMID: 18980987
23. Data show that ANKRD1 is a short-lived protein whose levels are tightly regulated by the 26S proteasome. PMID: 19589340
24. ANKRD1 is a novel DCM gene, with mutations present in 1.9% of DCM patients. The ANKRD1 mutations may cause DCM PMID: 19608030
25. CARP abnormalities may be involved in the pathogenesis of HCM. PMID: 19608031

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HGNC: 15819

OMIM: 106700

KEGG: hsa:27063

STRING: 9606.ENSP00000360762

UniGene: Hs.448589