AP1M2 Antibody

Datasheet

Code	CSB-PA895771ESR1HU
Size	US$166
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Image	Western blot All lanes: AP1M2 antibody at 2μg/ml Lane 1: Mouse small intestine tissue Lane 2: Mouse kidney tisueSecondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 48 kDa Observed band size: 48 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA895771ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA895771ESR1HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AP1M2 Polyclonal antibody

Uniprot No.

Q9Y6Q5

Target Names

AP1M2

Alternative Names

Adaptor protein complex AP-1 mu-2 subunit antibody; Adaptor protein complex AP1 mu2 subunit antibody; Adaptor related protein complex 1 mu2 subunit antibody; Adaptor-related protein complex 1 mu-2 subunit antibody; AP mu chain family member mu1B antibody; AP-1 complex subunit mu-2 antibody; AP-mu chain family member mu1B antibody; AP1 complex subunit mu2 antibody; AP1M2 antibody; AP1M2_HUMAN antibody; AP47 2 antibody; Clathrin assembly protein complex 1 medium chain 2 antibody; Golgi adaptor HA1/AP1 adaptin mu-2 subunit antibody; Golgi adaptor HA1/AP1 adaptin mu2 subunit antibody; HA1 47 kDa subunit 2 antibody; HSMU1B antibody; MU 1B antibody; Mu adaptin 2 antibody; Mu-adaptin 2 antibody; Mu1B adaptin antibody; Mu1B-adaptin antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human AP-1 complex subunit mu-2 protein (164-423AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Gene References into Functions

Variants in AP1M2 gene is associated with thrombosis. PMID: 26908601
Results suggest that mu1B interacts with different classes of basolateral targeting signals in distinct ways. PMID: 12134076
The AP1M2 gene was shown to effectively separate these two tumor(chromophobe renal cell carcinoma (RCC) and benign oncocytoma) groups by quantitative reverse transcription-PCR using fresh tissue samples, with similar trends seen on formalin-fixed tissues. PMID: 17145811
PIPKIgamma also interacts with the mu subunits of clathrin adaptor protein (AP) complexes PMID: 17261850
The mechanism of iron absorption from mineralized Soybean ferritin using Caco-2 cells via a mu2-dependent endocytosis mechanism is reported. PMID: 18356317

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Subcellular Location

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Protein Families

Adaptor complexes medium subunit family

Database Links

HGNC: 558

OMIM: 607309

KEGG: hsa:10053

STRING: 9606.ENSP00000250244

UniGene: Hs.18894

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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