AP2B1 Antibody

Code CSB-PA001871GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
AP2B1
Alternative Names
Adapter related protein complex 2 beta 1 subunit antibody; Adapter-related protein complex 2 beta subunit antibody; Adaptin, beta 2 (beta) antibody; Adaptor protein complex AP-2 subunit beta antibody; Adaptor related protein complex 2, beta 1 subunit antibody; ADTB2 antibody; AP-2 complex subunit beta antibody; AP105B antibody; AP2 BETA antibody; Ap2b1 antibody; AP2B1_HUMAN antibody; Beta adaptin antibody; Beta-2-adaptin antibody; Beta-adaptin antibody; Beta2 adaptin antibody; CLAPB1 antibody; Clathrin assembly protein complex 2 beta large chain antibody; Clathrin associated/assembly/adaptor protein, large, beta 1 antibody; DKFZp781K0743 antibody; Plasma membrane adaptor HA2/AP2 adaptin beta subunit antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human AP2B1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.
Gene References into Functions
  1. this study determined a structure of AP2 that includes the clathrin-binding beta2 hinge. PMID: 25061211
  2. Results suggest that autosomal recessive hypercholesterolemia (ARH) and beta-arrestin depend on a privileged AP2beta2 appendage site for proper cargo recruitment to clathrin bud sites. PMID: 18843039
  3. multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis PMID: 19903820
  4. interactions of the EGF receptor with AP-2 mediated by the receptor 974YRAL and di-leucine motifs may contribute to beta2 tyrosine phosphorylation PMID: 12900408
  5. AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. PMID: 16581796
  6. Clathrin, which interacts with the AP2beta-appendage, achieves ligand displacement in vivo by self-polymerisation as the coated pit matures. PMID: 16903783
  7. EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics. PMID: 19469909

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Subcellular Location
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
Protein Families
Adaptor complexes large subunit family
Tissue Specificity
Expressed in the brain (at protein level).
Database Links

HGNC: 563

OMIM: 601025

KEGG: hsa:163

STRING: 9606.ENSP00000314414

UniGene: Hs.514819

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